{"id":"W4402737549","doi":"10.1016/b978-0-323-99209-1.00014-4","title":"Inherited white matter disorders: Hypomyelination (myelin disorders)","year":2024,"lang":"en","type":"review","venue":"Handbook of clinical neurology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fondation de l'Hôpital de Montréal pour enfants","keywords":"White matter; Myelin; Leukodystrophy; Demyelinating Disorder; Neuroscience; Medicine; Psychology; Pathology; Magnetic resonance imaging; Central nervous system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005385628,0.001734858,0.002101755,0.003745509,0.0002912748,0.001249246,0.001333611,0.001398345,0.007329385],"category_scores_gemma":[0.0005612808,0.0003356068,0.0004729432,0.004309144,0.0006565446,0.001372122,0.001177935,0.00203809,0.008214287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006850949,"about_ca_system_score_gemma":0.001106992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00123971,"about_ca_topic_score_gemma":0.002974702,"domain_scores_codex":[0.9997783,0.00002735119,0.0000296883,0.00003788749,0.0001028015,0.00002395283],"domain_scores_gemma":[0.9997641,0.00009233035,0.00003782846,0.000008898714,0.00005647622,0.00004031345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007547685,0.00006230325,0.0001075915,0.007409713,0.00005219102,0.0002736007,0.00003161738,0.0002434144,0.001467449,0.002197528,0.09452239,0.8935567],"study_design_scores_gemma":[0.00002401658,0.00004718305,0.0007028666,0.002421333,0.00007003266,0.0024332,0.00003267261,0.00006377471,0.0002484927,0.001648624,0.9922904,0.00001740566],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005540798,0.9969245,0.0003022619,0.0002002856,0.000668797,0.000006007976,0.00003683456,0.00002536856,0.001780508],"genre_scores_gemma":[0.0004593061,0.9954032,0.0005880306,0.0003550698,0.0006393241,0.00001200964,0.00009988987,0.000004337781,0.002438836],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007329385,"threshold_uncertainty_score":0.02451921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04290586904229056,"score_gpt":0.3879172332701443,"score_spread":0.3450113642278538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}