{"id":"W4402741886","doi":"10.1016/j.eururo.2024.09.003","title":"Patient-reported Outcomes for Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1/2 Gene Alterations: Final Analysis from the Randomized Phase 3 MAGNITUDE Trial","year":2024,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Janssen Research and Development","keywords":"Medicine; Prostate cancer; Oncology; Randomized controlled trial; Internal medicine; Castration; Prostate; Orchiectomy; Gynecology; Urology; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01092322,0.001033129,0.002187379,0.0004967812,0.0002523782,0.0009837829,0.0006043392,0.0007155198,0.002014247],"category_scores_gemma":[0.005860775,0.0003637452,0.00430652,0.0007050518,0.0004570505,0.0007389217,0.0005831571,0.00135285,0.0002503555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006419267,"about_ca_system_score_gemma":0.001161928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003947869,"about_ca_topic_score_gemma":0.0008284553,"domain_scores_codex":[0.9940501,0.004659601,0.0002539887,0.0002823269,0.0004830765,0.0002709214],"domain_scores_gemma":[0.9966559,0.001276994,0.001276279,0.0003085307,0.0002235668,0.0002586051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9270793,0.002420726,0.02720898,0.00135063,0.01085842,0.0001075951,0.0001039858,0.002786225,0.003073169,0.0003472574,0.002455101,0.02220872],"study_design_scores_gemma":[0.6086255,0.1577233,0.2010206,0.0002507308,0.01821703,0.0003127104,0.0001154011,0.004245083,0.002023201,0.001119637,0.006247668,0.00009899658],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774497,0.006442388,0.001937563,0.0004591001,0.0001042568,0.003675966,0.007340988,0.000101808,0.00248822],"genre_scores_gemma":[0.9819238,0.001245181,0.00192769,0.0005200522,0.0001776962,0.004638446,0.008609868,0.00003578446,0.0009214036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01092322,"threshold_uncertainty_score":0.05776823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03850823502647392,"score_gpt":0.3445376374984897,"score_spread":0.3060294024720158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}