{"id":"W4402741886","doi":"10.1016/j.eururo.2024.09.003","title":"Patient-reported Outcomes for Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1/2 Gene Alterations: Final Analysis from the Randomized Phase 3 MAGNITUDE Trial","year":2024,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Janssen Research and Development","keywords":"Medicine; Prostate cancer; Oncology; Randomized controlled trial; Internal medicine; Castration; Prostate; Orchiectomy; Gynecology; Urology; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004150534,0.0001891528,0.0005298798,0.0001500336,0.0001553932,0.0001041764,0.00005256502,0.00001926652,0.0001108398],"category_scores_gemma":[0.0002506112,0.00009366898,0.0001563052,0.0002766289,0.0001981353,0.00007293327,0.00002769041,0.0001354973,0.00000559472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000357616,"about_ca_system_score_gemma":0.0002093487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001816635,"about_ca_topic_score_gemma":0.0001223796,"domain_scores_codex":[0.9982317,0.000421214,0.0004676755,0.0004040998,0.0002382483,0.0002370377],"domain_scores_gemma":[0.9985394,0.0008237825,0.000129096,0.0002280917,0.0001894125,0.00009024794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9511102,0.0008160099,0.0146915,0.00005614127,0.01561131,0.0005482815,0.002473583,0.00009105831,0.0004840606,0.00008994814,0.000702505,0.01332544],"study_design_scores_gemma":[0.9452643,0.004339383,0.03104413,0.00003025757,0.01270864,0.000007263387,0.00007638959,0.001862803,0.0001060455,0.0001123169,0.004243244,0.0002052466],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887482,0.002701723,0.0003701051,0.003546138,0.0001980669,0.003618221,0.0006652255,0.00004376256,0.0001085393],"genre_scores_gemma":[0.9959452,0.0002148803,0.000586992,0.0004713035,0.0001101927,0.0005909813,0.001502817,0.0000335629,0.0005440297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01635263,"threshold_uncertainty_score":0.381971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03850823502647392,"score_gpt":0.3445376374984897,"score_spread":0.3060294024720158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}