{"id":"W4402745861","doi":"10.1093/g3journal/jkae230","title":"Mistranslating tRNA variants have anticodon- and sex-specific impacts on <i>Drosophila melanogaster</i>","year":2024,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Institute on Aging","keywords":"Biology; Transfer RNA; Drosophila melanogaster; Genetics; Evolutionary biology; Drosophila (subgenus); Computational biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295128,0.0003798947,0.0001642064,0.0002403356,0.0001812447,0.000231002,0.0002058705,0.0002564068,0.001378382],"category_scores_gemma":[0.0001147615,0.000128062,0.0003130202,0.0001156258,0.0001948178,0.0001223118,0.0001739824,0.0004612641,0.0002200526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003349741,"about_ca_system_score_gemma":0.000137756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143465,"about_ca_topic_score_gemma":0.003166668,"domain_scores_codex":[0.9997932,0.00003130897,0.00003270047,0.00005688191,0.00005449598,0.00003151616],"domain_scores_gemma":[0.9997594,0.00004736578,0.00009993635,0.00002417309,0.00002510221,0.00004390091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006264821,0.00001475151,0.0004578911,0.00001641604,0.000005271201,0.00004562647,0.00001129393,0.00002291134,0.9986994,0.00003382207,0.00001722875,0.0006126649],"study_design_scores_gemma":[0.0000111367,0.0005455848,0.02885073,0.000006820516,0.00003088145,0.0003094975,0.00004942933,0.0005064423,0.9680889,0.00002554655,0.00156387,0.00001100706],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972575,0.0003187446,0.0006885835,0.00003658275,0.00001566872,0.00002394536,0.0006997754,0.0000377029,0.0009215359],"genre_scores_gemma":[0.9942491,0.0003350912,0.001833179,0.00009920894,0.00000757678,0.00004727154,0.0009066529,0.00004158325,0.002480339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378382,"threshold_uncertainty_score":0.004611194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097282084307728,"score_gpt":0.2633982547092702,"score_spread":0.2424254338661929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}