{"id":"W4402747955","doi":"10.1016/j.eclinm.2024.102799","title":"Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial","year":2024,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"NIHR Imperial Biomedical Research Centre; Imperial College London; National Institute for Health and Care Research","keywords":"Medicine; Escitalopram; Observational study; Randomized controlled trial; Depression (economics); Double blind; Psilocybin; Psychiatry; Major depressive disorder; Internal medicine; Placebo; Alternative medicine; Hallucinogen; Antidepressant; Anxiety; Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003155893,0.001868664,0.005092293,0.0005998202,0.0006913125,0.001101419,0.001118192,0.002648676,0.005600057],"category_scores_gemma":[0.004640101,0.001102629,0.003117666,0.0005761225,0.001230518,0.001421608,0.0005937226,0.002691878,0.001065435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000847565,"about_ca_system_score_gemma":0.001007074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183142,"about_ca_topic_score_gemma":0.002455141,"domain_scores_codex":[0.9979284,0.001176978,0.0002224636,0.0003279491,0.0001429947,0.0002012394],"domain_scores_gemma":[0.996841,0.0009225123,0.0009348796,0.0002768799,0.0002615158,0.0007632194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9889903,0.003919267,0.0006318741,0.0003806638,0.000708915,0.00001846492,0.00003594388,0.00008023213,0.0006851419,0.00001245472,0.0001606282,0.004376102],"study_design_scores_gemma":[0.8933836,0.102285,0.003228544,0.00002636611,0.0004795942,0.00001917486,0.00001894227,0.0001695855,0.0001388416,0.00003672835,0.0002000079,0.0000135258],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871395,0.004656719,0.0004714525,0.0004790763,0.0005135509,0.004603386,0.000979968,0.00008175895,0.001074589],"genre_scores_gemma":[0.9882029,0.002251871,0.000986299,0.0005923501,0.0006478971,0.005097146,0.0008628793,0.00001403111,0.00134467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005600057,"threshold_uncertainty_score":0.0187341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0456352541861727,"score_gpt":0.3942176578150705,"score_spread":0.3485824036288978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}