{"id":"W4402758970","doi":"10.1016/j.antiviral.2024.106010","title":"Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus","year":2024,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Capsid; Virology; Virus; Hepatitis B virus; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008765352,0.0005435204,0.0003699241,0.0002976774,0.0002314888,0.000514438,0.000392948,0.000367205,0.00229657],"category_scores_gemma":[0.0003638781,0.0002249961,0.0002861368,0.0001501279,0.0004245206,0.0003634861,0.0001590312,0.00133668,0.0004986592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916277,"about_ca_system_score_gemma":0.0005982054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005331829,"about_ca_topic_score_gemma":0.0008607305,"domain_scores_codex":[0.999788,0.0000839518,0.00001050263,0.00001695785,0.00003081903,0.00006972938],"domain_scores_gemma":[0.9998425,0.0000282861,0.00002588801,0.00001672124,0.00002492572,0.00006172316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01242179,0.01251163,0.001020065,0.0003853896,0.0001102315,0.0002295368,0.0001991559,0.001468124,0.9208733,0.0007442322,0.001530756,0.04850582],"study_design_scores_gemma":[0.01212787,0.3476815,0.01439541,0.0001141377,0.0003754638,0.001131171,0.0002516902,0.00380766,0.596943,0.0005477121,0.02258161,0.00004293246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99048,0.003875112,0.001650188,0.00030428,0.00007819387,0.0003580299,0.0003102468,0.00006370463,0.002880295],"genre_scores_gemma":[0.9935262,0.002366046,0.001179339,0.0001739414,0.00005950498,0.0001266941,0.0005808247,0.00001382592,0.001973649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00229657,"threshold_uncertainty_score":0.0076828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1261666485360752,"score_gpt":0.4585431319658281,"score_spread":0.3323764834297529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}