{"id":"W4402762147","doi":"10.1007/s10014-024-00493-w","title":"Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma","year":2024,"lang":"en","type":"article","venue":"Brain Tumor Pathology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of British Columbia; Ottawa Hospital; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Curing Kids Cancer; Cure Starts Now Foundation","keywords":"Histone deacetylase; Glioma; Medicine; Neurology; Neurosurgery; Carbonic anhydrase; Cancer research; Pathology; Pharmacology; Histone; Chemistry; Biochemistry; Enzyme; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002352114,0.0003069818,0.0002806061,0.0003343908,0.00008237173,0.00004993535,0.0001117262,0.0001522881,0.0000190073],"category_scores_gemma":[0.00003425693,0.0002666361,0.00007638763,0.0002419763,0.0003535139,0.00001292995,0.0001102506,0.0001871588,0.0000125234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250061,"about_ca_system_score_gemma":0.0001775288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001341111,"about_ca_topic_score_gemma":0.0004273068,"domain_scores_codex":[0.9980576,0.0002750925,0.0002921452,0.0007399078,0.0001882504,0.0004469834],"domain_scores_gemma":[0.9994055,0.00003719642,0.00005358221,0.000332339,0.00003627809,0.0001351002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003987594,0.0006394461,0.0002843729,0.00002662552,0.00003915029,0.004378994,0.0004165364,0.000007384046,0.9896664,0.00009602826,0.0003186722,0.00372761],"study_design_scores_gemma":[0.004665955,0.004845331,0.001176073,0.00004405677,0.00002914594,0.00255611,0.0002614474,0.0004447583,0.9832717,0.00002957686,0.002280281,0.0003955943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893737,0.008965869,0.00006366871,0.0006569386,0.0002345591,0.0005282084,0.00002187548,0.00004856329,0.0001065801],"genre_scores_gemma":[0.9986137,0.00006486494,0.00008733204,0.0001462131,0.0001826944,0.0001928651,0.0001297893,0.00006506866,0.0005174935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009239942,"threshold_uncertainty_score":0.9999786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007536261994977364,"score_gpt":0.2711580118906669,"score_spread":0.2636217498956895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}