{"id":"W4402763015","doi":"10.1084/jem.20240637","title":"Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients","year":2024,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Hospital Foundation; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; Stavros Niarchos Foundation; Hospital for Sick Children; Ministero della Salute; Fondation Bettencourt Schueller; CHIST-ERA; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; European Commission; SCOR Corporate Foundation for Science; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Meyer Foundation; Rockefeller University; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Fondation pour la Recherche Médicale; JPB Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut des maladies génétiques Imagine; Howard Hughes Medical Institute; Fondazione IRCCS Policlinico San Matteo; St. Giles Foundation; Ministry of Health","keywords":"Encephalitis; Medicine; Neutralization; Population; Tick-borne encephalitis; Autoantibody; Internal medicine; Virology; Immunology; Virus; Gastroenterology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003210262,0.0004247101,0.0003181603,0.0003361132,0.0004135228,0.000556337,0.0001921078,0.0004130274,0.002588361],"category_scores_gemma":[0.001347259,0.0002212075,0.0002743155,0.0002523318,0.0003533965,0.0003238907,0.0003469455,0.0005329634,0.0003401551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001921998,"about_ca_system_score_gemma":0.0002384501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552823,"about_ca_topic_score_gemma":0.001306959,"domain_scores_codex":[0.9996885,0.00007582864,0.00002610109,0.00007361376,0.00004818385,0.0000878655],"domain_scores_gemma":[0.9994581,0.0001138314,0.0002382277,0.00004482753,0.00004916894,0.00009580368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001628316,0.00002602626,0.991686,0.00001543897,0.000048037,0.001503139,0.0001084707,0.00007202211,0.001543448,0.00009384634,0.0003211368,0.004419539],"study_design_scores_gemma":[0.00001270723,0.0001412851,0.9817255,0.00002244261,0.00005935597,0.01613702,0.0003720267,0.0002183868,0.0003768373,0.0001462899,0.0007814855,0.000006560273],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974112,0.0006298561,0.0001834649,0.00008891858,0.00001183923,0.000008158659,0.00007513187,0.00001501815,0.001576436],"genre_scores_gemma":[0.9996908,0.00009082637,0.00003204969,0.00004365826,0.00001348496,0.000001451635,0.00004190081,0.000001383671,0.00008443533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002588361,"threshold_uncertainty_score":0.008658946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997285027835328,"score_gpt":0.3002534938559721,"score_spread":0.2802806435776188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}