{"id":"W4402763015","doi":"10.1084/jem.20240637","title":"Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients","year":2024,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Hospital Foundation; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; Stavros Niarchos Foundation; Hospital for Sick Children; Ministero della Salute; Fondation Bettencourt Schueller; CHIST-ERA; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; European Commission; SCOR Corporate Foundation for Science; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Meyer Foundation; Rockefeller University; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Fondation pour la Recherche Médicale; JPB Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut des maladies génétiques Imagine; Howard Hughes Medical Institute; Fondazione IRCCS Policlinico San Matteo; St. Giles Foundation; Ministry of Health","keywords":"Encephalitis; Medicine; Neutralization; Population; Tick-borne encephalitis; Autoantibody; Internal medicine; Virology; Immunology; Virus; Gastroenterology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002999346,0.0001353792,0.0003203174,0.000177179,0.00004774865,0.00000501064,0.0001926294,0.00006737463,0.001609626],"category_scores_gemma":[0.0001214313,0.00008110194,0.00006488296,0.0002075988,0.000359146,0.0001162054,0.00005016702,0.0002424469,0.00004854418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009829593,"about_ca_system_score_gemma":0.00007506231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001843109,"about_ca_topic_score_gemma":0.00001340224,"domain_scores_codex":[0.9989345,0.0002010959,0.0004983602,0.00009321528,0.00008695878,0.0001858884],"domain_scores_gemma":[0.9993005,0.0002801293,0.000177005,0.0001258026,0.0000932308,0.00002335343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008118968,0.0005625159,0.008905844,0.00007887882,0.0005148694,0.00006076049,0.009411067,0.0000169021,0.9621911,0.001580039,0.01474394,0.001122182],"study_design_scores_gemma":[0.007976155,0.01046617,0.1213539,0.003481064,0.0006472198,0.001363651,0.01902411,0.00001840729,0.8184808,0.0009792229,0.01571025,0.0004990946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456254,0.05085444,0.000005160128,0.0003938066,0.001574003,0.000104593,0.000009162198,0.0000169597,0.001416485],"genre_scores_gemma":[0.9990596,0.0003951626,0.000006947902,0.0001425733,0.00008536831,0.000001225627,0.00001051242,0.00001418639,0.000284482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1437103,"threshold_uncertainty_score":0.999303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997285027835328,"score_gpt":0.3002534938559721,"score_spread":0.2802806435776188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}