{"id":"W4402765463","doi":"10.3390/v16091506","title":"Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction","year":2024,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"RNA; Cell biology; Guide RNA; Viral replication; Biology; Virology; Capsid; Polyproteins; Group-specific antigen; Ribonucleoprotein; Chemistry; Virus; Genetics; Genome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536235,0.0003052575,0.0002760147,0.0001522653,0.000189778,0.0004377517,0.0002499333,0.0003594495,0.001434347],"category_scores_gemma":[0.0001614939,0.0001490079,0.0002018823,0.00008180137,0.0002467341,0.0003003184,0.0001754795,0.0004763851,0.0004400608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002604426,"about_ca_system_score_gemma":0.0001785974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002830102,"about_ca_topic_score_gemma":0.0003927156,"domain_scores_codex":[0.9998618,0.00003187835,0.00001554744,0.0000289238,0.00002724405,0.00003449983],"domain_scores_gemma":[0.9999154,0.00002343968,0.00002191994,0.00001201251,0.000009053492,0.00001820158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001941819,0.00003746603,0.0002005137,0.00003258356,0.000005986816,0.00006326105,0.000008824893,0.00007423064,0.9976603,0.00008113835,0.00002428722,0.001617306],"study_design_scores_gemma":[0.00002139239,0.0004258694,0.00169985,0.000002971264,0.00001207078,0.0001755165,0.000008850066,0.0004494711,0.9961702,0.00003392696,0.0009959592,0.000003827193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953281,0.001638384,0.0009705818,0.0001304243,0.00002160035,0.00002162366,0.0001164871,0.00007970106,0.001693149],"genre_scores_gemma":[0.9980002,0.0003189819,0.0009074081,0.00003540092,0.000008245869,0.00001068502,0.00006843622,0.000007249661,0.0006435297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001434347,"threshold_uncertainty_score":0.004798412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02939670754237052,"score_gpt":0.3089680910936937,"score_spread":0.2795713835513232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}