{"id":"W4402765742","doi":"10.1007/s00204-024-03856-6","title":"An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart","year":2024,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Manitoba; Dalhousie University; Health Canada; St. Boniface Hospital","funders":"Bundesinstitut für Risikobewertung; Health Canada; University of Manitoba","keywords":"Transcriptome; Oxylipin; Downregulation and upregulation; Biology; Metabolomics; Cardiotoxicity; Proteomics; Pharmacology; Biochemistry; Chemistry; Bioinformatics; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003536985,0.0006272888,0.0008708361,0.001398259,0.0005023144,0.0007423812,0.0002187227,0.0005127984,0.0006634649],"category_scores_gemma":[0.0001508207,0.0002144622,0.0009526214,0.001302683,0.000208178,0.0003330263,0.0004394555,0.0004641544,0.0002318884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002902153,"about_ca_system_score_gemma":0.0004527567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287154,"about_ca_topic_score_gemma":0.00184823,"domain_scores_codex":[0.9997491,0.00002159331,0.0000186461,0.0001015415,0.00007087159,0.00003828274],"domain_scores_gemma":[0.9999052,0.00001957371,0.00002130251,0.000009760303,0.00003066122,0.00001343065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004083262,0.00008006002,0.005738093,0.000228103,0.00009392478,0.0001297781,0.00008044231,0.0005873415,0.9852155,0.00007535517,0.0001640416,0.007198919],"study_design_scores_gemma":[0.00005482824,0.00138284,0.4473806,0.00009894179,0.0007434121,0.0009924463,0.001059136,0.03280121,0.5047014,0.001155408,0.009496097,0.0001337335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565772,0.002984085,0.01952952,0.0002361374,0.00005474656,0.0001512606,0.01893057,0.0002714819,0.001264934],"genre_scores_gemma":[0.8831128,0.003621081,0.07659159,0.0006248709,0.00005251315,0.000580342,0.03188298,0.0001199338,0.00341386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398259,"threshold_uncertainty_score":0.002559364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441126551345758,"score_gpt":0.2858360381890479,"score_spread":0.2714247726755903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}