{"id":"W4402787829","doi":"10.1016/j.bbi.2024.09.027","title":"Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides","year":2024,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institut polytechnique de Bordeaux; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fédération pour la Recherche sur le Cerveau; Fondation pour la Recherche Médicale; Canadian Institutes of Health Research; Faculty of Medicine, University of British Columbia; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques","keywords":"Adipose triglyceride lipase; Microglia; Lipolysis; Neuroinflammation; Lipid droplet; Inflammation; Chemistry; Lipopolysaccharide; Cell biology; Endocrinology; Internal medicine; Biology; Adipose tissue; Immunology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001968979,0.0006703553,0.000629039,0.0004279791,0.0002808199,0.0003633626,0.0003212273,0.0004855472,0.001618688],"category_scores_gemma":[0.0001156053,0.0001817876,0.0006001511,0.000232889,0.0003990577,0.0003205604,0.0002557105,0.001107863,0.0006428962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000387994,"about_ca_system_score_gemma":0.0005181543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006747812,"about_ca_topic_score_gemma":0.001146878,"domain_scores_codex":[0.9997383,0.00002893013,0.00004119223,0.00004474483,0.00005963085,0.00008718398],"domain_scores_gemma":[0.9998765,0.00001134072,0.00003651072,0.00001477592,0.00002131122,0.00003950752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004142686,0.00008173208,0.00008032073,0.0001295679,0.00001150114,0.00004202331,0.00001878953,0.00004894504,0.9975956,0.0000787539,0.00007565768,0.001422735],"study_design_scores_gemma":[0.00003854721,0.000590828,0.001224384,0.0000120196,0.0000260522,0.0001256174,0.00002215808,0.000290954,0.995598,0.00005255035,0.002013115,0.000005733522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981145,0.006376679,0.007035215,0.0005674099,0.00021497,0.0001771098,0.001256639,0.0004798736,0.002747058],"genre_scores_gemma":[0.9810926,0.004664235,0.006786885,0.0002689413,0.000054067,0.0003382383,0.001380813,0.00007481959,0.005339341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618688,"threshold_uncertainty_score":0.005415022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643542236737655,"score_gpt":0.2582042947458595,"score_spread":0.2417688723784829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}