{"id":"W4402787829","doi":"10.1016/j.bbi.2024.09.027","title":"Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides","year":2024,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institut polytechnique de Bordeaux; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fédération pour la Recherche sur le Cerveau; Fondation pour la Recherche Médicale; Canadian Institutes of Health Research; Faculty of Medicine, University of British Columbia; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques","keywords":"Adipose triglyceride lipase; Microglia; Lipolysis; Neuroinflammation; Lipid droplet; Inflammation; Chemistry; Lipopolysaccharide; Cell biology; Endocrinology; Internal medicine; Biology; Adipose tissue; Immunology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004171797,0.0001923372,0.0003387724,0.0004183496,0.00009002402,0.0000245036,0.00012341,0.0001867134,0.0003789228],"category_scores_gemma":[0.0002238055,0.0001809813,0.00007698822,0.0002046661,0.000249949,0.0001613893,0.0001468236,0.0004099,0.00002933709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002309995,"about_ca_system_score_gemma":0.00004920806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001524077,"about_ca_topic_score_gemma":0.00008060789,"domain_scores_codex":[0.9986488,0.0003387635,0.0005076392,0.000242967,0.0000402586,0.0002215842],"domain_scores_gemma":[0.9991268,0.0004401446,0.00009354794,0.0002402008,0.00006729174,0.00003204423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003958906,0.0001668577,0.05424683,0.00005989988,0.00002798298,0.000009058803,0.00134228,1.039856e-7,0.9389108,0.00003278178,0.0009604153,0.003847137],"study_design_scores_gemma":[0.0006264366,0.0004186449,0.6365116,0.0001631538,0.00005873279,0.0001449913,0.0007173279,0.000003194632,0.3555427,0.000003564674,0.005640485,0.0001691852],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948077,0.003601307,0.000003883562,0.0002268657,0.0009016134,0.0002921351,0.00005528312,0.00005129998,0.00005991751],"genre_scores_gemma":[0.9971383,0.0002799144,0.00001933566,0.00007923997,0.000009251443,0.00002686012,0.00007175932,0.00002011313,0.002355255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5833681,"threshold_uncertainty_score":0.7380205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643542236737655,"score_gpt":0.2582042947458595,"score_spread":0.2417688723784829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}