{"id":"W4402791359","doi":"10.1097/ede.0000000000001795","title":"Characterization of Additive Gene–environment Interactions For Colorectal Cancer Risk","year":2024,"lang":"en","type":"article","venue":"Epidemiology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Institutes of Health; Fred Hutchinson Cancer Research Center; Biobanco Vasco; Junta de Castilla y León; Medical Research Council; Servier; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; Medizinische Universität Graz; Grantová Agentura České Republiky; Institut Gustave-Roussy; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Ministerstvo Zdravotnictví Ceské Republiky; Imperial College London; Generalitat de Catalunya; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Canadian Cancer Society Research Institute; Marshfield Clinic Research Foundation; Institut National de la Santé et de la Recherche Médicale; Centres de Recerca de Catalunya; Conseil Régional des Pays de la Loire; Génome Québec; Swedish Cancer Foundation; Damon Runyon Cancer Research Foundation; Karl-Franzens-Universität Graz; Univerzita Karlova v Praze; McGill University; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute; University of Cambridge; University of Pittsburgh; Johns Hopkins University; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Association Anne de Bretagne Genetique; Brigham and Women's Hospital; Cancer Research UK; American Cancer Society; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Gene; Cancer; Oncology; Medicine; Computational biology; Genetics; Internal medicine; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000304646,0.00009710612,0.000165934,0.00004614102,0.00004723607,0.000002756328,0.00007614913,0.0001093003,0.0001730393],"category_scores_gemma":[0.0003209413,0.00009302235,0.0001086311,0.00004795819,0.0001057461,0.000003993956,0.00004141093,0.00007675142,0.00001244934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008289693,"about_ca_system_score_gemma":0.0001054707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003202195,"about_ca_topic_score_gemma":0.00003915617,"domain_scores_codex":[0.9990738,0.0001455921,0.0002789832,0.0003172299,0.00002799453,0.0001563685],"domain_scores_gemma":[0.9994293,0.0002322664,0.0001316937,0.0001333182,0.00004203615,0.00003131614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007692257,0.00002255644,0.002762651,0.00001945001,0.00021945,2.853373e-7,0.0000967179,0.0007408832,0.9696227,0.0003347798,0.005379042,0.02072459],"study_design_scores_gemma":[0.0001785637,0.0002196178,0.02137455,0.00001819509,0.00007789088,0.000008852745,0.00002573576,0.002855914,0.6366095,0.0006806936,0.3378118,0.0001386649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8873717,0.001457995,0.1067569,0.0009293869,0.001114478,0.0003184239,0.001915329,0.00001481088,0.0001210231],"genre_scores_gemma":[0.9891866,0.002831864,0.004090213,0.0002714829,0.0007931062,0.0007266604,0.001468006,0.00002665894,0.0006053373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3330132,"threshold_uncertainty_score":0.3793342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02217297160148127,"score_gpt":0.327138296521962,"score_spread":0.3049653249204807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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