{"id":"W4402801800","doi":"10.53539/squjs.splisspp34-44","title":"Cutting-Edge Approach to Targeted Therapy: Repositioning of Old Drugs in Combination with Standard Clinical Chemotherapeutics Potentiates a Propitious Novel Targeted Therapy for Human Pancreatic Cancer","year":2024,"lang":"en","type":"article","venue":"Maǧallaẗ ǧāmiʿaẗ al-Sulṭān Qābūs li-l-ʿulūm/Sultan Qaboos University journal for science","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Medicine; Pancreatic cancer; Targeted therapy; Cancer therapy; Oncology; Combination therapy; Cancer; Pharmacology; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420918,0.0002699966,0.0003141922,0.0003555357,0.0001392796,0.0003029269,0.0001903411,0.0001757251,0.001717811],"category_scores_gemma":[0.000061769,0.0001101657,0.0002442174,0.0001752442,0.000270883,0.0002612747,0.0002314526,0.0007244094,0.0002516705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140922,"about_ca_system_score_gemma":0.0002292373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000251192,"about_ca_topic_score_gemma":0.0009369811,"domain_scores_codex":[0.9999305,0.00001234538,0.000004133085,0.0000116991,0.00002351226,0.00001775222],"domain_scores_gemma":[0.9999764,0.000003691547,0.000005387662,0.000003661072,0.000003910382,0.000006916899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000899639,0.0008844288,0.0007291004,0.0005074025,0.00005051706,0.0002112751,0.00007374096,0.0006779272,0.8603485,0.002877278,0.001587436,0.1311527],"study_design_scores_gemma":[0.0004385897,0.01073571,0.01130369,0.0001147113,0.0002376253,0.001918884,0.0001017956,0.004914994,0.8803575,0.00154252,0.08830205,0.00003193756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9166484,0.05489888,0.01214873,0.002562602,0.0005669252,0.0002314245,0.0002775434,0.000354668,0.01231085],"genre_scores_gemma":[0.968252,0.02155801,0.004406451,0.0005373145,0.0001517027,0.0000768827,0.000165428,0.00001856255,0.004833751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001717811,"threshold_uncertainty_score":0.005746663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936776304811293,"score_gpt":0.3319781138248555,"score_spread":0.3026103507767425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}