{"id":"W4402809233","doi":"10.1371/journal.pone.0308821","title":"Update on a brain-penetrant cardiac glycoside that can lower cellular prion protein levels in human and guinea pig paradigms","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation","keywords":"In vivo; Guinea pig; Cell culture; Pharmacology; Human brain; Biology; Cell; Biochemistry; Chemistry; Neuroscience; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001508625,0.0008594385,0.0007466122,0.0009228903,0.0003437877,0.001153347,0.001071411,0.002554821,0.003775387],"category_scores_gemma":[0.0006958807,0.0003199644,0.000831468,0.0005032581,0.0005055402,0.001245637,0.0006062632,0.003876838,0.001497507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005889084,"about_ca_system_score_gemma":0.0005718755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006381879,"about_ca_topic_score_gemma":0.001712134,"domain_scores_codex":[0.9996727,0.0000747689,0.00004002575,0.0000487227,0.00010829,0.00005552872],"domain_scores_gemma":[0.999633,0.0001096978,0.00005558989,0.00001935682,0.0001144036,0.00006802745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002157758,0.002271772,0.001049657,0.01040612,0.0003573906,0.003571317,0.0004515235,0.0008218993,0.3284197,0.015146,0.1163737,0.5189732],"study_design_scores_gemma":[0.0001726905,0.003422708,0.0009277835,0.0006302946,0.0001974322,0.00215609,0.00006555093,0.0002131406,0.04252874,0.00191055,0.9477347,0.00004038075],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03392115,0.8920363,0.01546091,0.01638445,0.005004909,0.0004730595,0.001153185,0.0004968744,0.03506925],"genre_scores_gemma":[0.07278053,0.8528159,0.01790558,0.02046838,0.003513284,0.0007014024,0.002867927,0.0001609652,0.02878609],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003775387,"threshold_uncertainty_score":0.01262993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03042421161301254,"score_gpt":0.2422434012838221,"score_spread":0.2118191896708096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}