{"id":"W4402824750","doi":"10.1182/blood.2024026212","title":"Impact of soluble BCMA and non–T-cell factors on refractoriness to BCMA-targeting T-cell engagers in multiple myeloma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Multiple Myeloma Research Foundation","keywords":"Chimeric antigen receptor; Medicine; Multiple myeloma; Antigen; Cytotoxic T cell; Immunology; T cell; Internal medicine; Cancer research; Oncology; Biology; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005734687,0.0002279179,0.0003293485,0.0002973061,0.0001207217,0.0005253805,0.0001416146,0.0002608832,0.0009718274],"category_scores_gemma":[0.0009467824,0.00008864469,0.0002707367,0.0003128758,0.0002155789,0.0002231458,0.0002164054,0.0005299241,0.0001751671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004509817,"about_ca_system_score_gemma":0.0002371396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008299743,"about_ca_topic_score_gemma":0.0007501552,"domain_scores_codex":[0.999649,0.0001040105,0.0000367249,0.00007228339,0.00009430708,0.00004372352],"domain_scores_gemma":[0.9995154,0.0001905151,0.0001509485,0.00004033849,0.00005442786,0.00004834972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004437803,0.0003544368,0.2037483,0.0002802559,0.0004422675,0.0003704074,0.0001981674,0.003107816,0.7247083,0.0001769155,0.0002970255,0.0618784],"study_design_scores_gemma":[0.0001104383,0.005750375,0.5646922,0.00003468207,0.000554941,0.002337393,0.0001802401,0.01252954,0.4101014,0.0003149622,0.0033608,0.00003297333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973463,0.001673606,0.0004630884,0.00003894713,0.000005693379,0.00001280768,0.0001419422,0.00001762466,0.0003000226],"genre_scores_gemma":[0.9994593,0.0001353517,0.0001837642,0.00001979974,0.00000325067,0.000004159396,0.00009881504,0.000002477328,0.00009306207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009718274,"threshold_uncertainty_score":0.003272116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636482449823762,"score_gpt":0.3097894521498539,"score_spread":0.2834246276516163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}