{"id":"W4402825491","doi":"10.1212/wnl.0000000000209832","title":"Gene-Specific Effects on Brain Volume and Cognition of <i>TMEM106B</i> in Frontotemporal Lobar Degeneration","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Alzheimer Society; Parkinsonfonden; University of Toronto; University of California, San Diego; Alzheimer Society of B.C.; ACADIA Pharmaceuticals; Genentech; Eisai; University of Pennsylvania; CurePSP; University of Southern California; Pfizer; Biogen; Eli Lilly and Company; BrightFocus Foundation; AstraZeneca; Bristol-Myers Squibb; National Institutes of Health; National Ataxia Foundation; TauRx Pharmaceuticals; Alzheimer's Association","keywords":"Frontotemporal lobar degeneration; Frontotemporal dementia; Cognition; Neuroscience; Degeneration (medical); Psychology; Medicine; Pathology; Dementia; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004717619,0.000473403,0.0003202528,0.0005035741,0.0002763146,0.0003387648,0.0002781967,0.0005909897,0.002261856],"category_scores_gemma":[0.0008085138,0.0001577968,0.0005907338,0.0003334946,0.0003518622,0.000137014,0.0002362317,0.0003276483,0.0001617109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524846,"about_ca_system_score_gemma":0.0001099361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002913318,"about_ca_topic_score_gemma":0.003762939,"domain_scores_codex":[0.9996964,0.0001064265,0.0000291143,0.0001061504,0.00002879451,0.00003311284],"domain_scores_gemma":[0.9995073,0.000176447,0.0001740752,0.00005183673,0.00002072675,0.00006957616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02638422,0.0006677927,0.8262309,0.0001104807,0.00221146,0.002931312,0.0004776986,0.001455576,0.1229856,0.000404105,0.0007984139,0.0153424],"study_design_scores_gemma":[0.00010232,0.0005837022,0.9957825,0.00001014896,0.0002663708,0.0005845152,0.00006447662,0.0007280337,0.001484828,0.0001575742,0.0002278288,0.000007771911],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995645,0.00008720641,0.00006941624,0.00003061969,0.000004300284,0.000002094624,0.0001153279,0.00000624381,0.0001203178],"genre_scores_gemma":[0.9995502,0.00002409297,0.000120662,0.00002655084,0.000005740028,0.000004772995,0.0001122907,0.000005324965,0.0001504087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002913318,"threshold_uncertainty_score":0.007566631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02089721182188541,"score_gpt":0.2759065360003958,"score_spread":0.2550093241785104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}