{"id":"W4402826911","doi":"10.1056/nejmoa2314076","title":"Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Merck","keywords":"Ulcerative colitis; Monoclonal antibody; Medicine; Monoclonal; Antibody; Immunology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001960313,0.001610172,0.002053486,0.0005210084,0.0003956889,0.001051962,0.0008728619,0.001679955,0.005674714],"category_scores_gemma":[0.001512897,0.0006364984,0.001306844,0.0003065518,0.0006298009,0.0007983301,0.0004153367,0.003067296,0.0009780127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008602713,"about_ca_system_score_gemma":0.001371252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006747626,"about_ca_topic_score_gemma":0.001631604,"domain_scores_codex":[0.9994016,0.0003136904,0.00001976603,0.0000900507,0.00005926715,0.0001157143],"domain_scores_gemma":[0.9991847,0.0001879376,0.0002056883,0.0000723667,0.00006643066,0.0002828506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9104111,0.03141661,0.001892717,0.0006407255,0.0009449552,0.0001455167,0.0001079755,0.0009219616,0.01037822,0.0001938122,0.002800945,0.04014542],"study_design_scores_gemma":[0.8590242,0.1353918,0.002703329,0.00003022639,0.0002114071,0.00008984252,0.00001574889,0.0004697722,0.0006822072,0.0001008737,0.001267463,0.00001310659],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851609,0.003535214,0.0008640109,0.001258807,0.0004859814,0.004940819,0.001310127,0.0001629632,0.002281187],"genre_scores_gemma":[0.9768217,0.002437732,0.002242267,0.002310554,0.0007705031,0.007718814,0.002789117,0.00004068334,0.004868466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005674714,"threshold_uncertainty_score":0.01898384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469134885743377,"score_gpt":0.3319288127097137,"score_spread":0.3172374638522799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}