{"id":"W4402827484","doi":"10.3390/cells13191606","title":"A Novel Bioluminescent Biosensor Quantifying Intramolecular Interaction and Levels of Pyroptosis Effector GSDMD","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Cancer Society","keywords":"Pyroptosis; Biosensor; Programmed cell death; Effector; Chemistry; Apoptosis; Computational biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000871663,0.0001192806,0.0001155452,0.00006405898,0.000027813,0.00003256217,0.0000625497,0.00009293192,0.00001637066],"category_scores_gemma":[0.00002336901,0.0001097327,0.00008340227,0.00008637134,0.00006300677,0.000005094586,0.00005776017,0.00006545267,0.0000166843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006896334,"about_ca_system_score_gemma":0.00002229427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001958462,"about_ca_topic_score_gemma":0.000003955169,"domain_scores_codex":[0.9993734,0.00002142918,0.000166565,0.000240091,0.00005757923,0.000140875],"domain_scores_gemma":[0.9997229,0.00001403485,0.00003688331,0.0001588776,0.00003795172,0.00002933642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002921546,0.00003262825,0.00009682067,0.0001826399,0.00007325203,0.000001938674,0.00007893833,0.00000714591,0.9928502,0.00003222507,0.0001966199,0.006418387],"study_design_scores_gemma":[0.0002289715,0.000140619,0.0005766867,0.00008852928,0.0000279287,0.000007700878,0.0001189413,0.0002064007,0.9835926,0.00000213577,0.01487889,0.0001306047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994363,0.002496796,0.002234866,0.0000487977,0.0004350089,0.0001402833,0.00003010857,0.00001328752,0.0002378985],"genre_scores_gemma":[0.9990812,0.0002872605,0.0003282399,0.00004727816,0.00006491233,0.000006202854,0.00003498024,0.00002045873,0.0001294751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01468227,"threshold_uncertainty_score":0.4474768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901790941211065,"score_gpt":0.268430696329422,"score_spread":0.2494127869173114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}