{"id":"W4402827484","doi":"10.3390/cells13191606","title":"A Novel Bioluminescent Biosensor Quantifying Intramolecular Interaction and Levels of Pyroptosis Effector GSDMD","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Cancer Society","keywords":"Pyroptosis; Biosensor; Programmed cell death; Effector; Chemistry; Apoptosis; Computational biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005757347,0.0007221702,0.000475111,0.0004379264,0.0001889887,0.0004448453,0.000999685,0.001383371,0.0004811062],"category_scores_gemma":[0.0004940943,0.0002861071,0.0002962205,0.0004102175,0.0003707308,0.0006491656,0.0005237443,0.0008697609,0.0003083234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007707727,"about_ca_system_score_gemma":0.0003213024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003309727,"about_ca_topic_score_gemma":0.0003931324,"domain_scores_codex":[0.9995166,0.00009774191,0.00003396897,0.0001313806,0.000180148,0.00004018212],"domain_scores_gemma":[0.9998135,0.00004883559,0.00005118965,0.00001365631,0.00003694039,0.00003598185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002626796,0.00002341154,0.0001264256,0.00004598674,0.000004190018,0.00002098771,0.00001057419,0.0000930048,0.9975401,0.0001541201,0.00006339201,0.00189156],"study_design_scores_gemma":[0.00001210752,0.0001231133,0.000406166,0.000005775508,0.000008342993,0.0001518222,0.00001929371,0.004184503,0.9934655,0.00006748465,0.001540503,0.00001550348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7006143,0.005432487,0.2876248,0.00141732,0.0003507644,0.0002021009,0.0007974333,0.001115842,0.002444954],"genre_scores_gemma":[0.7688171,0.002190439,0.2235131,0.0007734393,0.00004010861,0.0002649667,0.0006242419,0.00004477312,0.003731837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383371,"threshold_uncertainty_score":0.005592406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901790941211065,"score_gpt":0.268430696329422,"score_spread":0.2494127869173114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}