{"id":"W4402827770","doi":"10.1038/s41375-024-02420-6","title":"Pola-R-CHP or R-CHOEP for first-line therapy of younger patients with high-risk diffuse large B-cell lymphoma: a retrospective comparison of two randomized phase 3 trials","year":2024,"lang":"en","type":"article","venue":"Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; Swedish Orphan Biovitrum; F. Hoffmann-La Roche; Incyte; BeiGene; Gilead Sciences; MorphoSys; Celgene; Eli Lilly and Company; AstraZeneca; Agios Pharmaceuticals; Roche; Amgen","keywords":"Lymphoma; Medicine; Retrospective cohort study; Oncology; Internal medicine; Randomized controlled trial; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008614624,0.0003651617,0.002525644,0.0001780654,0.00008149023,0.00002821155,0.0001027863,0.0001298866,0.0001140544],"category_scores_gemma":[0.0005038402,0.0001924751,0.0005825289,0.0003151839,0.0001246956,0.0001062638,0.00002749991,0.00008974315,0.000007702724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008030202,"about_ca_system_score_gemma":0.0004478954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009540169,"about_ca_topic_score_gemma":0.0001056375,"domain_scores_codex":[0.9974104,0.0002066558,0.001105395,0.0004657023,0.0004794098,0.0003324657],"domain_scores_gemma":[0.9964957,0.001993293,0.0006465658,0.0004243929,0.0003037623,0.0001363477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7697752,0.05570864,0.1354226,0.0007164057,0.005922779,0.00006943992,0.003737684,0.00001665276,0.0006541003,0.002094634,0.004721983,0.02115988],"study_design_scores_gemma":[0.9460847,0.005316978,0.01265366,0.0004420152,0.002126816,0.000002531789,0.00005804739,0.001754191,0.02960007,0.0002468301,0.001496583,0.0002175297],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896776,0.003422518,0.0009595841,0.0001260988,0.0003382018,0.004001813,0.001285503,0.00006916038,0.0001195088],"genre_scores_gemma":[0.9965569,0.0009792446,0.0009647943,0.00009276257,0.0001873003,0.0005516827,0.0003396731,0.00006332273,0.000264268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1763096,"threshold_uncertainty_score":0.7848905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574011826774529,"score_gpt":0.3359160215656327,"score_spread":0.3101759032978874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}