{"id":"W4402843541","doi":"10.1016/j.chembiol.2024.08.014","title":"Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration","year":2024,"lang":"en","type":"review","venue":"Cell chemical biology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Charlie Teo Foundation; Ministry of Health, State of Israel; Garvan Institute of Medical Research; Mark Foundation For Cancer Research; Deutsche Forschungsgemeinschaft; Fondation Brain Canada; European Crohn's and Colitis Organisation; Israel Science Foundation; Canadian Institute for Advanced Research; Leona M. and Harry B. Helmsley Charitable Trust; Ministry of Science and Technology, Israel; Wellcome Trust; Howard Hughes Medical Institute; Alexander von Humboldt-Stiftung; Bill and Melinda Gates Foundation; Minerva Foundation","keywords":"Neurodegeneration; Microbiome; Neuroscience; Computational biology; Biology; Bioinformatics; Medicine; Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001903258,0.0008073437,0.001309112,0.0001273752,0.00007440228,0.00005357027,0.0005137078,0.001578509,0.00004767136],"category_scores_gemma":[0.00005494812,0.0005707916,0.0005184822,0.0002695582,0.0001023472,0.000002370046,0.0002918305,0.0006024154,0.0003127142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006181269,"about_ca_system_score_gemma":0.0003306314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007237714,"about_ca_topic_score_gemma":0.000003091573,"domain_scores_codex":[0.9970676,0.0002426096,0.0006462727,0.001293923,0.00005828112,0.0006913663],"domain_scores_gemma":[0.998735,0.0000424298,0.000247118,0.0006668666,0.00008189071,0.0002266857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001458148,0.0000856612,9.371293e-8,0.002378591,0.0001010453,0.000001072998,0.000007531721,3.383281e-8,0.9585603,0.0001009809,0.02398715,0.01476299],"study_design_scores_gemma":[0.0001063186,0.0001448084,3.909159e-8,0.0002260773,0.0001864436,0.00001996493,0.000001834644,4.373541e-7,0.4580332,0.00005184869,0.5409099,0.0003190202],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003395342,0.9937364,0.00009256972,0.00009729923,0.0006951572,0.0005958253,0.001007936,0.00005440125,0.0003250193],"genre_scores_gemma":[0.003406633,0.9816034,0.0002335237,0.0006432874,0.0004367221,0.000087792,0.01297723,0.0001343216,0.000477049],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5169228,"threshold_uncertainty_score":0.9997177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01834166318386168,"score_gpt":0.2895368421986514,"score_spread":0.2711951790147897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}