{"id":"W4402852659","doi":"10.1101/2024.09.21.24313023","title":"Associations of Genetic Variants in the Dopamine Transporter with Problematic Sexual Behavior and Reward Deficiency Syndrome","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; NOSM University; Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Innovates","keywords":"Dopamine transporter; Dopamine; Sexual behavior; Psychology; Transporter; Genetics; Clinical psychology; Neuroscience; Biology; Gene; Dopaminergic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917584,0.0001622081,0.0002026813,0.00007484364,0.00002378858,0.00002765881,0.0001797437,0.0001573564,0.00001358504],"category_scores_gemma":[0.0000227253,0.0001103921,0.00003618532,0.000107725,0.0000620249,0.000001253885,0.00008166283,0.0001813003,0.000001886844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000674276,"about_ca_system_score_gemma":0.00007978655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005289042,"about_ca_topic_score_gemma":0.0002758982,"domain_scores_codex":[0.9989575,0.00007465177,0.0003087928,0.0003371613,0.0001828681,0.0001390096],"domain_scores_gemma":[0.9995078,0.00001296653,0.0001170471,0.0002988872,0.00003588078,0.00002736694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002538004,0.0006158935,0.9730203,0.001035395,0.0001335714,0.00006264328,0.00199759,0.0001776229,0.02206863,0.0001450292,0.00006115053,0.0006568389],"study_design_scores_gemma":[0.0002840002,0.0002056915,0.9982827,0.00005279629,0.0001726369,0.00003038085,0.0002330506,0.00003986229,0.0001965061,0.0003474828,0.000008686045,0.0001461959],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978509,0.0009261137,0.0002216418,0.0001362157,0.00007391341,0.0005175292,0.0001130123,0.000007305118,0.0001533773],"genre_scores_gemma":[0.9991032,0.00003239444,0.00021755,0.00004439634,0.00001305091,0.0001417465,0.0003438531,0.00001847821,0.00008530416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02526246,"threshold_uncertainty_score":0.450166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969075111403927,"score_gpt":0.2634605807146289,"score_spread":0.2437698296005896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}