{"id":"W4402862056","doi":"10.3390/cancers16193280","title":"IDH2 Inhibitors Gain a Wildcard Status in the Cancer Therapeutics Competition","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Ministero dell'Istruzione e del Merito; Associazione Italiana per la Ricerca sul Cancro","keywords":"IDH2; Cancer research; Triple-negative breast cancer; Cancer; Reprogramming; Cancer cell; Immunotherapy; CD8; Biology; Immune system; Cell; Immunology; Breast cancer; IDH1; Biochemistry; Mutation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002854518,0.0002663918,0.000351576,0.000180788,0.0001877194,0.0006609928,0.0003713465,0.0007961884,0.00175299],"category_scores_gemma":[0.0003598145,0.00008954902,0.0002336256,0.0001270496,0.0004448169,0.0006533621,0.0002829015,0.001246404,0.0007306795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005907571,"about_ca_system_score_gemma":0.0003360589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001773167,"about_ca_topic_score_gemma":0.0006367247,"domain_scores_codex":[0.9998253,0.00003080916,0.00001445835,0.00003158638,0.00007241904,0.00002544415],"domain_scores_gemma":[0.9999045,0.00003578759,0.00001332861,0.000006305545,0.00002404265,0.00001592558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001078457,0.0001394518,0.001120746,0.002146543,0.0001538271,0.002630007,0.0002426818,0.002102191,0.2573713,0.08634537,0.1590932,0.4875762],"study_design_scores_gemma":[0.00005443946,0.0003198523,0.0006620631,0.0001704403,0.00005578034,0.002170672,0.00006085197,0.0005585587,0.04976609,0.006975399,0.9391867,0.0000191188],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07264122,0.7404348,0.01410924,0.0778103,0.03281737,0.00009751625,0.0004302763,0.0006022582,0.06105711],"genre_scores_gemma":[0.3920239,0.4824049,0.006785239,0.03548041,0.01241933,0.0001069351,0.0003449172,0.0001341431,0.07030019],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00175299,"threshold_uncertainty_score":0.005864382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435630123010533,"score_gpt":0.281443834310019,"score_spread":0.2670875330799137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}