{"id":"W4402887948","doi":"10.1080/17425255.2024.2409257","title":"A high-throughput liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of <i>p</i> -cresol sulfate, <i>p</i> -cresol glucuronide, indoxyl sulfate, and indoxyl glucuronide in HepaRG culture medium and the demonstration of mefenamic acid as a potent and selective detoxifying agent","year":2024,"lang":"en","type":"article","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chromatography; Glucuronide; Chemistry; Tandem mass spectrometry; Sulfate; Mass spectrometry; Liquid chromatography–mass spectrometry; Metabolite; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007877193,0.001477814,0.0007088782,0.001557765,0.00072003,0.0007004721,0.0008327188,0.001325011,0.000980827],"category_scores_gemma":[0.0009120752,0.0005373919,0.0006777401,0.0009437455,0.0005312253,0.0006245066,0.0005665948,0.00105808,0.00104742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006919134,"about_ca_system_score_gemma":0.001153373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008433283,"about_ca_topic_score_gemma":0.00262136,"domain_scores_codex":[0.9983531,0.000216353,0.000110453,0.0003647977,0.0008672034,0.00008802958],"domain_scores_gemma":[0.9994254,0.0001081669,0.000158684,0.00005160167,0.000179667,0.00007646887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007928914,0.0001244274,0.000913251,0.0000725049,0.0000351779,0.00008684994,0.00002436758,0.0001524536,0.9936101,0.00009336611,0.0002033561,0.004604865],"study_design_scores_gemma":[0.00002296597,0.0003059674,0.004645451,0.00001647883,0.0000462013,0.0006481621,0.00002243695,0.00491722,0.9871669,0.00009018728,0.002083715,0.00003426013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4906037,0.00771808,0.4786451,0.0008294185,0.0004331331,0.001957972,0.007653743,0.005387577,0.00677126],"genre_scores_gemma":[0.6000775,0.005205435,0.3725786,0.001376427,0.0002324843,0.003128546,0.007217715,0.000228763,0.009954507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557765,"threshold_uncertainty_score":0.005020261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02534594208674377,"score_gpt":0.3312251915654957,"score_spread":0.3058792494787519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}