{"id":"W4402896743","doi":"10.1136/ijgc-2024-005484","title":"Patient-reported outcomes in the subpopulation of patients with mismatch repair-deficient/microsatellite instability-high primary advanced or recurrent endometrial cancer treated with dostarlimab plus chemotherapy compared with chemotherapy alone in the ENGOT-EN6-NSGO/GOG3031/RUBY trial","year":2024,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Genentech; PharmaMar; Eisai; Natera; Seagen; MacroGenics; Tarveda Therapeutics; Mersana Therapeutics; Clovis Oncology; Novocure; Pfizer; Intuitive Surgical; Regeneron Pharmaceuticals; Gilead Sciences; Sanofi; Amgen; AstraZeneca; Eli Lilly and Company; GlaxoSmithKline","keywords":"Carboplatin; Medicine; Endometrial cancer; Placebo; Clinical endpoint; Internal medicine; Quality of life (healthcare); Population; Oncology; Paclitaxel; Chemotherapy; Microsatellite instability; Cancer; Randomized controlled trial; Surgery; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002226163,0.0004217866,0.00138642,0.0002033145,0.0002161103,0.0005377542,0.0003290551,0.0005739806,0.001305101],"category_scores_gemma":[0.001882381,0.0001926128,0.001324502,0.000234826,0.000291653,0.0003745083,0.0003013492,0.000895102,0.0001555694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407349,"about_ca_system_score_gemma":0.0003278271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001759594,"about_ca_topic_score_gemma":0.0004716051,"domain_scores_codex":[0.9992486,0.0004778896,0.00005744738,0.00009002695,0.00006121994,0.00006480547],"domain_scores_gemma":[0.9992562,0.0002471051,0.0002803998,0.00004826168,0.00003078058,0.0001372402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8212633,0.003411266,0.09861168,0.001038339,0.005475077,0.0002902213,0.0001942218,0.001684254,0.007730903,0.0001718372,0.001332214,0.0587967],"study_design_scores_gemma":[0.3147537,0.269076,0.3891806,0.0002648626,0.01054261,0.001208929,0.0002716572,0.004776907,0.004013036,0.001176012,0.004641684,0.00009414662],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964945,0.002382846,0.0001256071,0.000167334,0.00003152219,0.0001256689,0.0002422291,0.000005631817,0.0004248417],"genre_scores_gemma":[0.9985111,0.0004373309,0.0001684249,0.0001470248,0.00005428292,0.0001956372,0.0003071626,0.000001601529,0.0001775149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002226163,"threshold_uncertainty_score":0.01177317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813212996517463,"score_gpt":0.3225475539439214,"score_spread":0.2944154239787468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}