{"id":"W4402899934","doi":"10.1016/j.bbadis.2024.167529","title":"Impaired hippocampal plasticity associated with loss of recycling endosomal SLC9A6/NHE6 is ameliorated by the TrkB agonist 7,8-dihydroxyflavone","year":2024,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Institute of Neurosciences, Mental Health and Addiction; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Tropomyosin receptor kinase B; Agonist; Hippocampal formation; Endosome; Neuroplasticity; Neuroscience; Pharmacology; Chemistry; Medicine; Internal medicine; Psychology; Receptor; Neurotrophic factors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558466,0.0007359192,0.0007939893,0.0005332489,0.0003398243,0.0003535303,0.0005021943,0.0006583278,0.002880514],"category_scores_gemma":[0.000159269,0.0003194831,0.0005196944,0.0002634505,0.0007935642,0.0004418216,0.0002942749,0.001678656,0.0006912809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004596475,"about_ca_system_score_gemma":0.0005107131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001736,"about_ca_topic_score_gemma":0.002922851,"domain_scores_codex":[0.9997657,0.00002682382,0.00003245605,0.00003999067,0.00005163893,0.00008346735],"domain_scores_gemma":[0.9996924,0.00001501079,0.0001243876,0.00003229366,0.00002120408,0.0001146943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001056602,0.0001083957,0.000218946,0.00004511265,0.00002220799,0.0003111957,0.00002104592,0.00004543418,0.996815,0.00009946449,0.0001107359,0.001145727],"study_design_scores_gemma":[0.0002037277,0.001000494,0.01331979,0.00001673687,0.00007510729,0.001485796,0.0001574583,0.0007889555,0.9812267,0.0001973725,0.001506672,0.0000211705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966452,0.0007479027,0.0007304591,0.0002665975,0.00008282492,0.00001854622,0.0004832413,0.0001872529,0.0008380008],"genre_scores_gemma":[0.9958565,0.0005834787,0.0006336528,0.00007051448,0.00001570648,0.00002968056,0.0003993911,0.0000299546,0.00238114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002880514,"threshold_uncertainty_score":0.009636283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238612969227379,"score_gpt":0.294002795501708,"score_spread":0.2716166658094342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}