{"id":"W4402903820","doi":"10.1126/sciimmunol.adj8094","title":"Twin study identifies early immunological and metabolic dysregulation of CD8 <sup>+</sup> T cells in multiple sclerosis","year":2024,"lang":"en","type":"article","venue":"Science Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Multiple sclerosis; Neuroinflammation; CD8; Immunology; Proinflammatory cytokine; Subclinical infection; Biology; T cell; Phenotype; Cell; Cytotoxic T cell; Immune system; Inflammation; Genetics; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001437895,0.0003790959,0.0007582548,0.001283577,0.000407865,0.0001087569,0.0009091739,0.0004611535,0.0002904129],"category_scores_gemma":[0.0002437043,0.0003197083,0.0001480345,0.001649124,0.004803662,0.0006339889,0.0007030492,0.0007599607,0.0004371716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007891157,"about_ca_system_score_gemma":0.000201621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510064,"about_ca_topic_score_gemma":0.00008993693,"domain_scores_codex":[0.9964929,0.0005061629,0.0008663711,0.001061601,0.0001298544,0.0009430943],"domain_scores_gemma":[0.9984776,0.0004976434,0.0001676039,0.0006751957,0.0001520582,0.00002983366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001763749,0.0004631284,0.01055438,0.00001625805,0.0002188837,0.00001650913,0.004673615,0.00004496898,0.9706489,0.001450793,0.00002564581,0.01171051],"study_design_scores_gemma":[0.002233462,0.001034341,0.2124681,0.00009127354,0.00009754325,0.00008720253,0.005391372,0.0001899603,0.7758198,0.0007297059,0.001446911,0.0004104051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660745,0.03131706,0.00002951066,0.0001490737,0.001463035,0.0006230468,0.0000196732,0.0001573715,0.0001666958],"genre_scores_gemma":[0.9980593,0.0008304308,0.00008858228,0.00002391974,0.00001928732,0.00007278143,0.00001334441,0.00002401958,0.0008683213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2019137,"threshold_uncertainty_score":0.9999255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02608701754223889,"score_gpt":0.2429323325306119,"score_spread":0.216845314988373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}