{"id":"W4402903820","doi":"10.1126/sciimmunol.adj8094","title":"Twin study identifies early immunological and metabolic dysregulation of CD8 <sup>+</sup> T cells in multiple sclerosis","year":2024,"lang":"en","type":"article","venue":"Science Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Multiple sclerosis; Neuroinflammation; CD8; Immunology; Proinflammatory cytokine; Subclinical infection; Biology; T cell; Phenotype; Cell; Cytotoxic T cell; Immune system; Inflammation; Genetics; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003159438,0.0004333683,0.0004463045,0.0005019705,0.00049613,0.0004717791,0.0002072583,0.0002990943,0.00179046],"category_scores_gemma":[0.001012339,0.0002855468,0.0002744691,0.0004700341,0.0002894342,0.0001559904,0.0004936551,0.0005490897,0.0001509481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516371,"about_ca_system_score_gemma":0.0001038953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0034546,"about_ca_topic_score_gemma":0.003912162,"domain_scores_codex":[0.999667,0.00008864247,0.00002528513,0.0001376359,0.00004942418,0.00003199158],"domain_scores_gemma":[0.9995642,0.00005449389,0.0001570736,0.00008977071,0.00004670079,0.00008779075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003638095,0.00007350499,0.8886179,0.00009939583,0.0007697496,0.001895472,0.001225384,0.0002363175,0.09101678,0.0007766795,0.0005599989,0.01109075],"study_design_scores_gemma":[0.00002359134,0.0003548579,0.9872227,0.00002162246,0.0003090693,0.004494941,0.0002721559,0.0005221874,0.005246868,0.0003560771,0.001160258,0.00001565721],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981316,0.0003371384,0.0008967934,0.00003262661,0.00001310459,0.000006349542,0.0002457306,0.000007149883,0.0003295871],"genre_scores_gemma":[0.9988043,0.0001327267,0.0004855172,0.00002363466,0.000005320118,0.000005299585,0.0001480386,0.00001124831,0.0003838507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0034546,"threshold_uncertainty_score":0.006868958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02608701754223889,"score_gpt":0.2429323325306119,"score_spread":0.216845314988373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}