{"id":"W4402903934","doi":"10.1126/sciadv.adq7006","title":"Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"Medizinischen Hochschule Hannover","keywords":"Vaccination; Immunology; Influenza vaccine; Medicine; Vaccine efficacy; Population; Inflammation; Serology; Antibody; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004645592,0.0002298255,0.0003787641,0.0004715223,0.0001842701,0.0004474771,0.0001388728,0.0002471975,0.0008692328],"category_scores_gemma":[0.0005051717,0.0001298009,0.0002177615,0.0003161754,0.0001915319,0.0002715261,0.0003415227,0.0002752993,0.0001768448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410609,"about_ca_system_score_gemma":0.0001610306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013296,"about_ca_topic_score_gemma":0.00124806,"domain_scores_codex":[0.9998529,0.00003251782,0.00001013989,0.00005779043,0.00001632517,0.00003026609],"domain_scores_gemma":[0.9997211,0.00003456742,0.0001357963,0.00003650592,0.00003342657,0.00003867803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008995119,0.00006752721,0.86992,0.000084659,0.0002077756,0.0001997792,0.0003473098,0.0002369324,0.1164298,0.0001147206,0.0001945679,0.01129742],"study_design_scores_gemma":[0.000002399369,0.0002376702,0.995994,0.000007494935,0.00005688309,0.0001855461,0.0001920568,0.0002754216,0.002540029,0.0001163802,0.0003878748,0.000004211332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980887,0.0007807032,0.0005086915,0.00003637467,0.000005497644,0.000004913822,0.0003976036,0.000005433428,0.0001721739],"genre_scores_gemma":[0.9988315,0.0002691071,0.0002791044,0.00003590779,0.0000100124,0.000008771848,0.0003183857,0.000002766124,0.0002444337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013296,"threshold_uncertainty_score":0.002907932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007199125646775328,"score_gpt":0.2797082693306552,"score_spread":0.2725091436838799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}