{"id":"W4402903934","doi":"10.1126/sciadv.adq7006","title":"Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"Medizinischen Hochschule Hannover","keywords":"Vaccination; Immunology; Influenza vaccine; Medicine; Vaccine efficacy; Population; Inflammation; Serology; Antibody; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00067388,0.00007079535,0.00007021091,0.0002901548,0.0002152594,0.00007458625,0.000114512,0.00003816144,0.00001733918],"category_scores_gemma":[0.0001298141,0.00004700127,0.00001573608,0.0005500549,0.00009769991,0.0009551356,0.0000256548,0.0001271075,0.00005013643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006534131,"about_ca_system_score_gemma":0.0000297945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006152388,"about_ca_topic_score_gemma":0.00001743622,"domain_scores_codex":[0.9992601,0.0001700186,0.0001696837,0.0002229768,0.00005306051,0.0001242063],"domain_scores_gemma":[0.9996879,0.0001185139,0.00003982861,0.000114058,0.00003338132,0.000006336606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001419969,0.000006466197,0.0009855272,0.00001929894,0.000003027483,0.000002726015,0.002475582,0.0002199808,0.9834689,0.0008812455,0.00002957363,0.01176565],"study_design_scores_gemma":[0.001412681,0.0007378678,0.2406107,0.001064452,0.0000462221,0.0005628418,0.01369491,0.002751489,0.5887996,0.005786727,0.1439603,0.0005722091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747964,0.02276053,0.0002669694,0.0004859602,0.001426153,0.0001284863,1.199143e-7,0.00003957352,0.00009585264],"genre_scores_gemma":[0.9994041,0.00005095272,0.00002336726,0.0003185721,0.00001088197,0.00001151889,0.000005805265,0.000003452708,0.0001712956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3946693,"threshold_uncertainty_score":0.1916656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007199125646775328,"score_gpt":0.2797082693306552,"score_spread":0.2725091436838799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}