{"id":"W4402905733","doi":"10.1016/j.jchromb.2024.124328","title":"An unconventional strategy for purifying recombinant SARS-CoV-2 spike protein","year":2024,"lang":"en","type":"article","venue":"Journal of Chromatography B","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Chemistry; Recombinant DNA; Chromatography; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike (software development); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Spike Protein; Virology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003955678,0.0007953212,0.000489459,0.0003902808,0.0003147448,0.0005941109,0.0007688049,0.0007892889,0.001186494],"category_scores_gemma":[0.0002865171,0.0002796297,0.0006520937,0.0003974349,0.0002684053,0.0005269448,0.0007684145,0.001327216,0.001784059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004183751,"about_ca_system_score_gemma":0.0006006666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006631157,"about_ca_topic_score_gemma":0.001170787,"domain_scores_codex":[0.999333,0.00008378916,0.00005945736,0.0001272612,0.0003203374,0.00007620365],"domain_scores_gemma":[0.9998259,0.00001753891,0.00003256401,0.00004255569,0.0000559248,0.00002562637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000319009,0.00005694152,0.0001428712,0.0001441845,0.00001502416,0.00008565741,0.00003327812,0.00008401195,0.9904221,0.0003780226,0.00051526,0.008090811],"study_design_scores_gemma":[0.00001462249,0.0001860972,0.001290297,0.00001844415,0.00003416277,0.0008305685,0.00002644625,0.001775466,0.9699031,0.0002000144,0.02569093,0.00003002476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5155028,0.009403598,0.4555808,0.001749599,0.0007983798,0.001342287,0.002467667,0.002052933,0.01110185],"genre_scores_gemma":[0.5931505,0.008945369,0.3565172,0.00130336,0.0001405267,0.0009594331,0.01069605,0.0004256021,0.02786199],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001186494,"threshold_uncertainty_score":0.003969193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06589403858331457,"score_gpt":0.3876789406182209,"score_spread":0.3217849020349063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}