{"id":"W4402908725","doi":"10.1016/j.ijrobp.2024.08.014","title":"Interim Futility Results of NRG-HN005, A Randomized, Phase II/III Non-Inferiority Trial for Non-Smoking p16+ Oropharyngeal Cancer Patients","year":2024,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Radiomics and Machine Learning in Medical Imaging","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Interim; Medicine; Interim analysis; Randomized controlled trial; Cancer; Internal medicine; Oncology; Political science; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002362944,0.0002452435,0.001230233,0.0002599199,0.00009557467,0.0000385092,0.0003530772,0.0002480022,0.00006423755],"category_scores_gemma":[0.002144753,0.0001972111,0.0006599635,0.0001748123,0.0004126789,0.0002722311,0.0001001537,0.0008604848,0.000002076864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006896633,"about_ca_system_score_gemma":0.001032887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001028816,"about_ca_topic_score_gemma":0.000003267719,"domain_scores_codex":[0.997059,0.0002352947,0.00167816,0.0003403132,0.0004153721,0.0002718936],"domain_scores_gemma":[0.9959957,0.001240619,0.001336533,0.0001532948,0.001094657,0.0001792146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5049257,0.002578625,0.006326701,0.0001161263,0.002626671,0.00005478736,0.002194224,0.0002275071,0.00428523,0.001225858,0.006219039,0.4692195],"study_design_scores_gemma":[0.8604898,0.005921425,0.000959368,0.0005217498,0.0007688552,0.00004865716,0.0000523025,0.10315,0.002167988,0.003066424,0.02261898,0.0002343847],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9267794,0.0005206359,0.05496964,0.004205998,0.01174416,0.001069967,0.0002375948,0.00003210774,0.0004404291],"genre_scores_gemma":[0.9915863,0.0006435009,0.001571269,0.000531963,0.005278749,0.00005890006,0.0002220619,0.0000337768,0.0000734593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4689851,"threshold_uncertainty_score":0.8042035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095768943247512,"score_gpt":0.3941854739643185,"score_spread":0.3732277845318434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}