{"id":"W4402908725","doi":"10.1016/j.ijrobp.2024.08.014","title":"Interim Futility Results of NRG-HN005, A Randomized, Phase II/III Non-Inferiority Trial for Non-Smoking p16+ Oropharyngeal Cancer Patients","year":2024,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Radiomics and Machine Learning in Medical Imaging","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Interim; Medicine; Interim analysis; Randomized controlled trial; Cancer; Internal medicine; Oncology; Political science; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003667615,0.00121287,0.002016221,0.0002716444,0.0003780633,0.001195106,0.0008403279,0.001403765,0.01209534],"category_scores_gemma":[0.004253775,0.0003192249,0.002924818,0.000297059,0.0009060325,0.001214011,0.0004986768,0.003516506,0.001360935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001156452,"about_ca_system_score_gemma":0.001390662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009288759,"about_ca_topic_score_gemma":0.003061764,"domain_scores_codex":[0.9987441,0.0008099696,0.00004790627,0.0001341255,0.00008627793,0.0001775103],"domain_scores_gemma":[0.9977838,0.001006837,0.0003865222,0.0002005845,0.0001072131,0.000515052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9114867,0.003584883,0.001520679,0.0008975114,0.001945782,0.00009830175,0.0001148389,0.003358423,0.003742626,0.0007571258,0.007202473,0.06529077],"study_design_scores_gemma":[0.851053,0.1262797,0.007312264,0.000190081,0.002067159,0.0001473583,0.00009178543,0.003074344,0.001432754,0.002675432,0.005627192,0.00004891214],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600565,0.009529649,0.002769592,0.004700501,0.001185539,0.002599169,0.005135088,0.0004303564,0.0135936],"genre_scores_gemma":[0.9741266,0.002083277,0.002631287,0.003934297,0.0004475852,0.00256423,0.0060438,0.0001045858,0.008064444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209534,"threshold_uncertainty_score":0.04046291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095768943247512,"score_gpt":0.3941854739643185,"score_spread":0.3732277845318434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}