{"id":"W4402909416","doi":"10.1016/j.ijrobp.2024.07.1081","title":"Enhancing Radiotherapy Response via Intratumoral Injection of the TLR9 Agonist CpG to Stimulate CD8 T Cells in an Autochthonous Mouse Model of Sarcoma","year":2024,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"TLR9; Agonist; CD8; Cancer research; CpG site; Sarcoma; Cytotoxic T cell; Biology; Chemistry; Medicine; Immunology; Internal medicine; Receptor; Immune system; Pathology; Gene; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002445593,0.0006544979,0.0003757628,0.0005297571,0.0001571096,0.000250312,0.0003077199,0.0007790427,0.001930761],"category_scores_gemma":[0.0001301443,0.000216613,0.0003673053,0.0002006363,0.0003990052,0.0003041087,0.0001768556,0.001774308,0.0004478686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452256,"about_ca_system_score_gemma":0.0003703319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005924422,"about_ca_topic_score_gemma":0.0009837792,"domain_scores_codex":[0.9997599,0.00003359962,0.00001746129,0.00005659324,0.00005584649,0.00007657415],"domain_scores_gemma":[0.9998759,0.00002014452,0.00003198337,0.00002200826,0.00001078044,0.00003927567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008677327,0.0007602622,0.0001116664,0.00006976438,0.00001040087,0.00007219625,0.00003342499,0.0005220394,0.9946139,0.0002197135,0.0001719968,0.002546893],"study_design_scores_gemma":[0.0003276626,0.006868307,0.001450388,0.00001911065,0.0000605689,0.000265524,0.00005129764,0.003811778,0.9846901,0.0001739944,0.002267365,0.00001392696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944238,0.0005927001,0.002175891,0.0002470407,0.0001864116,0.0001157236,0.0003736582,0.0001817239,0.001703034],"genre_scores_gemma":[0.9918886,0.0005460107,0.002425043,0.0001369021,0.00004580384,0.0001684214,0.0002965869,0.00002509056,0.004467699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930761,"threshold_uncertainty_score":0.006459057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955691720854546,"score_gpt":0.3348380867185227,"score_spread":0.3152811695099773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}