{"id":"W4402915161","doi":"10.1101/2024.09.26.24314049","title":"Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Rosetrees Trust; National Institute for Health and Care Research; Cancer Research UK","keywords":"Hepatocellular carcinoma; Oncolytic virus; Medicine; Intravenous therapy; Virus; Oncology; Internal medicine; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009892521,0.000277518,0.0005349845,0.0001959,0.00007876626,0.0006615244,0.000372406,0.0002619632,0.0007893554],"category_scores_gemma":[0.001030019,0.0001366602,0.000228957,0.0001280984,0.0002074847,0.0003953876,0.0001830324,0.0006562709,0.0001406734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004876491,"about_ca_system_score_gemma":0.0003849721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002865695,"about_ca_topic_score_gemma":0.0004981257,"domain_scores_codex":[0.9997278,0.0001370054,0.00001944651,0.00003207179,0.00004706903,0.00003661878],"domain_scores_gemma":[0.9996145,0.0001637253,0.0001323263,0.00003182291,0.00001845207,0.00003922049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01175377,0.001755769,0.006601642,0.0006237986,0.0001385326,0.0001856727,0.0001283309,0.04847534,0.6702015,0.001508198,0.000705348,0.257922],"study_design_scores_gemma":[0.002712807,0.06954697,0.03512403,0.0003759496,0.0007418238,0.001726977,0.0004607874,0.2435172,0.6207233,0.003982604,0.02093928,0.0001481985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9490396,0.01728245,0.0304386,0.0008686737,0.000159797,0.0002585868,0.00009307073,0.00017526,0.001683884],"genre_scores_gemma":[0.9907889,0.001470362,0.007267638,0.0000707086,0.00004771665,0.00005562509,0.00002740228,0.00001750685,0.0002541547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009892521,"threshold_uncertainty_score":0.005231738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05689571319455186,"score_gpt":0.3248596014582518,"score_spread":0.2679638882636999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}