{"id":"W4402917665","doi":"10.1111/apt.18278","title":"Eight‐year efficacy and safety of tenofovir alafenamide for treatment of chronic hepatitis B virus infection: Final results from two randomised phase 3 trials","year":2024,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Gilead Sciences","keywords":"Tenofovir alafenamide; Medicine; Internal medicine; Gastroenterology; Renal function; HBeAg; Hepatitis B virus; Hepatitis B; Creatinine; Immunology; HBsAg; Viral load; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005756299,0.000304085,0.001208635,0.0001585626,0.0001096702,0.00000878426,0.00006048256,0.0001017006,0.0003775779],"category_scores_gemma":[0.000007112134,0.0002388955,0.0002940729,0.0001517351,0.0003084522,0.00007273017,0.00003550036,0.0000963989,0.000008777463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003407896,"about_ca_system_score_gemma":0.000280466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005717928,"about_ca_topic_score_gemma":0.001147711,"domain_scores_codex":[0.9975914,0.0003840178,0.001139876,0.0004173665,0.0001779816,0.0002893711],"domain_scores_gemma":[0.9962897,0.003029841,0.0002831508,0.0002068885,0.0000952561,0.00009510794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1364353,0.003259288,0.01012153,0.0002724509,0.06275371,0.0001122068,0.002775865,0.00007081131,0.700705,0.00004924981,0.001229578,0.082215],"study_design_scores_gemma":[0.3159131,0.01096895,0.004807342,0.0002150024,0.03992429,0.00001980331,0.0000165707,0.002878648,0.5765682,0.0001495348,0.04826545,0.0002730422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705769,0.01916297,0.0002948423,0.002089254,0.001184546,0.003194246,0.003361397,0.00006291288,0.00007296223],"genre_scores_gemma":[0.8969533,0.09973973,0.0006942457,0.0007688554,0.000882932,0.0002004037,0.0005811542,0.00004488046,0.0001344455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1794778,"threshold_uncertainty_score":0.9741877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0980559863978301,"score_gpt":0.4164252887409187,"score_spread":0.3183693023430886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}