{"id":"W4402925018","doi":"10.1002/btpr.3507","title":"<scp>CHO</scp> stable pool fed‐batch process development of <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 spike protein production: Impact of aeration conditions and feeding strategies","year":2024,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; National Research Council Canada","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"Bioreactor; Aeration; Continuous stirred-tank reactor; Chinese hamster ovary cell; Biology; Chemistry; Pulp and paper industry; Biochemistry; Ecology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003258733,0.0003303731,0.0003136134,0.0001612316,0.0001787322,0.0003791564,0.0002757485,0.0002432187,0.0005502087],"category_scores_gemma":[0.0001825775,0.0001126064,0.0003240646,0.0002606721,0.0001203615,0.0002172642,0.0001754574,0.0003795725,0.0003500576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003629153,"about_ca_system_score_gemma":0.0003594221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313486,"about_ca_topic_score_gemma":0.002080658,"domain_scores_codex":[0.9998295,0.00002336879,0.000020991,0.00003111627,0.00007476901,0.00002024587],"domain_scores_gemma":[0.9999152,0.00001666391,0.00001930701,0.00001410695,0.00002465902,0.000009965122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002814648,0.00001644989,0.00005360119,0.00001447445,0.00000187334,0.00001489668,0.000005970063,0.0001161531,0.9990243,0.00001938635,0.00002434723,0.0006804178],"study_design_scores_gemma":[0.000003245198,0.0001235242,0.0004977297,0.000001428304,0.000004227695,0.00002071537,0.000005968411,0.00115177,0.9978224,0.000007150218,0.0003591021,0.000002777801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753126,0.0002400583,0.02180738,0.00007203487,0.00001678767,0.0001709968,0.0008940048,0.000236087,0.00125006],"genre_scores_gemma":[0.9364873,0.000493363,0.05660495,0.00004460107,0.000008080166,0.0002240961,0.002016917,0.00008894463,0.004031751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313486,"threshold_uncertainty_score":0.002633154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200971823803156,"score_gpt":0.2983084650320178,"score_spread":0.2862987467939863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}