{"id":"W4402925018","doi":"10.1002/btpr.3507","title":"<scp>CHO</scp> stable pool fed‐batch process development of <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 spike protein production: Impact of aeration conditions and feeding strategies","year":2024,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; National Research Council Canada","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"Bioreactor; Aeration; Continuous stirred-tank reactor; Chinese hamster ovary cell; Biology; Chemistry; Pulp and paper industry; Biochemistry; Ecology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002988361,0.0004429283,0.0004273057,0.0003502616,0.0003421282,0.0001710418,0.0003222269,0.0008099052,0.000004882765],"category_scores_gemma":[0.0005197994,0.0003939895,0.0001670796,0.0006237391,0.000622307,0.00008015224,0.0002479086,0.0003423546,0.00000679124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006341999,"about_ca_system_score_gemma":0.0007419158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002283641,"about_ca_topic_score_gemma":0.00002719776,"domain_scores_codex":[0.997504,0.00007256455,0.0006453597,0.000893395,0.0002937343,0.0005909604],"domain_scores_gemma":[0.9986033,0.00004202753,0.0003789767,0.0004765434,0.0003790304,0.0001200792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009924904,0.0003274459,0.00295982,0.0008558129,0.0003867747,0.00001013123,0.0005722627,0.0001333905,0.9855842,0.0005575434,0.006737874,0.001864805],"study_design_scores_gemma":[0.0003953737,0.0009025168,0.001643992,0.0003581523,0.00006979486,0.00006006618,0.002344568,0.0001324818,0.9837017,0.000793753,0.009519088,0.00007849755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902664,0.006253954,0.0008674714,0.00009756468,0.0003490249,0.001448971,0.0001219023,0.0002273866,0.0003673488],"genre_scores_gemma":[0.9968679,0.0002454837,0.001120979,0.00001387337,0.0002110534,0.0006761515,0.0002273471,0.00005891729,0.0005783004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006601519,"threshold_uncertainty_score":0.9998512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200971823803156,"score_gpt":0.2983084650320178,"score_spread":0.2862987467939863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}