{"id":"W4402925737","doi":"10.3390/cancers16193293","title":"A Comprehensive Review of the Antitumor Properties and Mechanistic Insights of Duocarmycin Analogs","year":2024,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories; Response Biomedical (Canada)","funders":"","keywords":"Chemistry; Computational biology; DNA; Mechanism of action; Stereochemistry; Pharmacology; Biochemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002585622,0.0006560211,0.000932218,0.001555993,0.0002058515,0.0006146626,0.0005068376,0.0004891243,0.00394068],"category_scores_gemma":[0.0003456389,0.0002727973,0.0004767505,0.001452738,0.0001851495,0.0008010452,0.0003547747,0.000889723,0.00136427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000405725,"about_ca_system_score_gemma":0.000693417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005749566,"about_ca_topic_score_gemma":0.0009194227,"domain_scores_codex":[0.9998724,0.00002211509,0.00002100104,0.00002410211,0.00004452998,0.00001575373],"domain_scores_gemma":[0.9998893,0.00004127077,0.0000241483,0.000004391731,0.00002787028,0.00001297007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002660718,0.0001827034,0.000261916,0.0550298,0.0001669703,0.0004756134,0.000154962,0.001612834,0.02620569,0.005625402,0.04780415,0.8622139],"study_design_scores_gemma":[0.00001602757,0.0002384716,0.0006046098,0.001910902,0.0001178178,0.000831923,0.00003051447,0.0001267615,0.002915392,0.0006990672,0.9924892,0.00001937225],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008959406,0.995748,0.000359764,0.0001716672,0.0001947881,0.00001552011,0.0001269316,0.00002277671,0.00246467],"genre_scores_gemma":[0.003451181,0.9940335,0.0004817832,0.0002547413,0.0001565911,0.00002100161,0.0002282267,0.000004825099,0.001368178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00394068,"threshold_uncertainty_score":0.01318288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06207976238552604,"score_gpt":0.3116229086495274,"score_spread":0.2495431462640014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}