{"id":"W4402925791","doi":"10.1007/s40262-024-01424-w","title":"Physiologically Based Pharmacokinetic Modelling in Critically Ill Children Receiving Anakinra While on Extracorporeal Life Support","year":2024,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"University of Waterloo; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Foundation for the National Institutes of Health","keywords":"Critically ill; Anakinra; Extracorporeal; Life support; Medicine; Intensive care medicine; Pharmacokinetics; Extracorporeal membrane oxygenation; Anesthesia; Pharmacology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001562373,0.0007689042,0.001206581,0.0005266477,0.0001130544,0.0001639903,0.0005496035,0.0004607327,0.002397744],"category_scores_gemma":[0.0009844262,0.0006718716,0.0007223837,0.0009801728,0.0005141224,0.0001253615,0.0001873642,0.002619677,0.000558192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001154538,"about_ca_system_score_gemma":0.0004970112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001242351,"about_ca_topic_score_gemma":8.165505e-7,"domain_scores_codex":[0.9936056,0.0003322419,0.00234945,0.001614701,0.0008860562,0.001212019],"domain_scores_gemma":[0.9957356,0.001546389,0.0001943292,0.0006743225,0.0005778234,0.001271493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01021951,0.02308246,0.1267582,0.00302871,0.002247009,0.009063812,0.0003520423,0.3218684,0.05450529,0.003535606,0.1550824,0.2902566],"study_design_scores_gemma":[0.007390303,0.002233313,0.1071462,0.0009199865,0.0009187492,0.0000674421,0.00001366495,0.8513789,0.002189708,0.0003377433,0.02633558,0.001068453],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956126,0.001157574,0.01480485,0.009122374,0.002659524,0.001908174,0.0001730263,0.0008274572,0.01322099],"genre_scores_gemma":[0.962168,0.002356658,0.00570155,0.02656996,0.002325978,0.00002627582,0.0002665222,0.000195977,0.0003891229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5295104,"threshold_uncertainty_score":0.9996813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09297391029454456,"score_gpt":0.3993955792869996,"score_spread":0.306421668992455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}