{"id":"W4402929404","doi":"10.1101/2024.09.26.615202","title":"The glia club: Validation of polarization biomarkers for human microglia (HMC3) using quantitative real time RT-qPCR","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg","funders":"","keywords":"Microglia; Real-time polymerase chain reaction; Computational biology; Neuroscience; Computer science; Biology; Immunology; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003962031,0.001898507,0.001359619,0.001779848,0.001122738,0.001577816,0.0007717303,0.001020469,0.004248765],"category_scores_gemma":[0.001780577,0.0008584101,0.000983977,0.001851877,0.001306154,0.000481481,0.000982393,0.001761628,0.003433372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007910007,"about_ca_system_score_gemma":0.001512603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002226331,"about_ca_topic_score_gemma":0.003671454,"domain_scores_codex":[0.9950413,0.0008440944,0.0003934469,0.001386899,0.001938562,0.0003956376],"domain_scores_gemma":[0.9985215,0.0003890809,0.0002002511,0.0002414168,0.000574674,0.00007310788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002266718,0.00008038217,0.001424211,0.0002290227,0.00003004132,0.00004701416,0.0002194562,0.0004164696,0.9866051,0.0003774064,0.001009018,0.009335355],"study_design_scores_gemma":[0.00003102277,0.0003477772,0.005451465,0.000060547,0.00007016518,0.0001723436,0.00007664874,0.003392394,0.9790967,0.0003550054,0.01090725,0.00003871189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3838916,0.004830758,0.5370904,0.0009616009,0.001052428,0.003861303,0.04381004,0.01002698,0.01447499],"genre_scores_gemma":[0.2863268,0.003015671,0.6375182,0.001149574,0.0002515817,0.01173603,0.03364692,0.003054611,0.02330052],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004248765,"threshold_uncertainty_score":0.02095342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04015583228027032,"score_gpt":0.2833765102724657,"score_spread":0.2432206779921954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}