{"id":"W4402939005","doi":"10.1073/pnas.2318098121","title":"Poly ADP-ribose signaling is dysregulated in Huntington disease","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto; McMaster University","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Canadian Institutes of Health Research; School of Medicine, Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Genentech; Medical Research Council Centre for Neurodevelopmental Disorders; Krembil Foundation; National Institute of General Medical Sciences; Ontario Genomics Institute; University of Toronto; University College London; European Federation of Pharmaceutical Industries and Associations; McMaster University; Merck KGaA; National Institutes of Health; Ontario Genomics; F. Hoffmann-La Roche; Genome Canada; University of California, Irvine; CHDI Foundation; McGill University; National Cancer Institute; Bayer; Johns Hopkins University; Pfizer; UK Research and Innovation; Bristol-Myers Squibb","keywords":"Huntington's disease; Cytosine; Guanine; Disease; Ribose; Cancer research; Genetics; Chemistry; Biology; Medicine; Biochemistry; DNA; Internal medicine; Nucleotide; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005122985,0.000279311,0.00009683161,0.0001558117,0.0001435517,0.0002179058,0.00007964764,0.0002976345,0.001388558],"category_scores_gemma":[0.00004515849,0.00007705141,0.00007675148,0.0001359969,0.000135551,0.00007016234,0.0001053947,0.0002931757,0.0003633747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686787,"about_ca_system_score_gemma":0.00009821921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005363579,"about_ca_topic_score_gemma":0.0008600975,"domain_scores_codex":[0.999958,0.000006017161,0.000002704734,0.00001505831,0.00001200423,0.000006054247],"domain_scores_gemma":[0.9999814,0.000002567727,0.000006299363,0.000001702848,0.000002072649,0.000006035657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001151052,0.00002395022,0.0007726271,0.00006230555,0.00001201029,0.0003566605,0.00001127454,0.00004828113,0.9887129,0.0001924276,0.0003684671,0.009323925],"study_design_scores_gemma":[0.00005156691,0.000603482,0.1236213,0.000039291,0.0000815059,0.004891511,0.00009267777,0.002103199,0.830874,0.0007219291,0.03690881,0.00001070787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683362,0.0179894,0.005446028,0.0006906292,0.0001390558,0.00004588635,0.001662403,0.000318396,0.005372016],"genre_scores_gemma":[0.9823193,0.006826965,0.002281172,0.0001504698,0.0000228429,0.00004337158,0.001668596,0.00001076274,0.006676489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001388558,"threshold_uncertainty_score":0.004645169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04619173505586426,"score_gpt":0.3533474717573959,"score_spread":0.3071557367015317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}