{"id":"W4402939082","doi":"10.1093/cercor/bhae386","title":"Aβ remotely and locally facilitates Alzheimer’s disease tau spreading","year":2024,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Amyloid (mycology); Neuroscience; Magnetic resonance imaging; Functional magnetic resonance imaging; Amyloid beta; Alzheimer's disease; Connectome; BETA (programming language); Pathology; Psychology; Medicine; Disease; Functional connectivity; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002877715,0.0002122785,0.0001754728,0.0003233588,0.0002169599,0.0004088434,0.0001543937,0.0002005782,0.0008838371],"category_scores_gemma":[0.000859359,0.0001907297,0.0001977142,0.0002079977,0.00025405,0.0004070666,0.0002324369,0.000183935,0.0001201027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518686,"about_ca_system_score_gemma":0.0001079041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399122,"about_ca_topic_score_gemma":0.00168993,"domain_scores_codex":[0.9999045,0.00002942277,0.00000740585,0.00002983488,0.00001484219,0.00001398929],"domain_scores_gemma":[0.9997713,0.00005774214,0.00008572554,0.00003646359,0.00002557829,0.00002323364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002027221,0.0004997393,0.6071652,0.0002047692,0.0005564502,0.001669594,0.001252951,0.003213933,0.3430132,0.001832073,0.0004291493,0.0381358],"study_design_scores_gemma":[0.00002667078,0.000444449,0.9794286,0.00001729576,0.0001269872,0.0009837288,0.0003242675,0.00228218,0.01347759,0.002414647,0.0004604121,0.00001329602],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992441,0.00008694871,0.0002932567,0.00001188369,0.000001006568,0.000002132822,0.00003511378,0.000003741781,0.0003219096],"genre_scores_gemma":[0.9995124,0.0001002938,0.0002478955,0.000005270986,0.000002383688,0.00000394179,0.00004785068,0.000001502778,0.00007834659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399122,"threshold_uncertainty_score":0.002956748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04999069755085119,"score_gpt":0.2807251110305388,"score_spread":0.2307344134796876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}