{"id":"W4402939082","doi":"10.1093/cercor/bhae386","title":"Aβ remotely and locally facilitates Alzheimer’s disease tau spreading","year":2024,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Amyloid (mycology); Neuroscience; Magnetic resonance imaging; Functional magnetic resonance imaging; Amyloid beta; Alzheimer's disease; Connectome; BETA (programming language); Pathology; Psychology; Medicine; Disease; Functional connectivity; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051006,0.0001970272,0.0001632633,0.00009995216,0.0002420365,0.0001784731,0.0001325122,0.00003874983,0.0001160089],"category_scores_gemma":[0.002567122,0.0001746605,0.00007722891,0.0002640976,0.0002647252,0.0003635949,0.0001804215,0.0001883171,0.0003531055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000390211,"about_ca_system_score_gemma":0.00007137741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003277804,"about_ca_topic_score_gemma":0.00001738164,"domain_scores_codex":[0.9984521,0.00007143382,0.0001630183,0.0007457609,0.0002659558,0.0003017827],"domain_scores_gemma":[0.9973877,0.002161226,0.00002332437,0.0002143986,0.00002798657,0.0001853806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00089587,0.0003308743,0.03100684,0.001083874,0.000474476,0.002539863,0.003974636,0.0002050584,0.3333099,0.1490646,0.1744455,0.3026685],"study_design_scores_gemma":[0.001535747,0.0009123422,0.5699401,0.0008245342,0.0005908713,0.000371644,0.000788562,0.05977163,0.04301231,0.08795982,0.2316481,0.002644249],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688376,0.00653451,0.0006167734,0.01377181,0.001771719,0.0004818966,0.0001593058,0.0007982545,0.007028094],"genre_scores_gemma":[0.9960595,0.00006403604,0.00007697054,0.002022363,0.000142395,0.00001344722,0.00000346381,0.00002545906,0.001592369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5389333,"threshold_uncertainty_score":0.7122449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04999069755085119,"score_gpt":0.2807251110305388,"score_spread":0.2307344134796876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}