{"id":"W4402940732","doi":"10.2196/64950","title":"Efficacy and Safety of a Therapy Combining Sintilimab and Chemotherapy With Cryoablation in the First-Line Treatment of Advanced Nonsquamous Non–Small Cell Lung Cancer: Protocol for a Phase II, Pilot, Single-Arm, Single-Center Study","year":2024,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Oncology; Cryoablation; Lung cancer; Chemotherapy; Protocol (science); Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006820811,0.002260399,0.002875783,0.0009451903,0.001095757,0.001193776,0.002017357,0.002322775,0.006654508],"category_scores_gemma":[0.002564566,0.0009389821,0.001930562,0.0008810019,0.001833961,0.001176686,0.0007231843,0.003529761,0.001616708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002012046,"about_ca_system_score_gemma":0.005354621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008149073,"about_ca_topic_score_gemma":0.001403953,"domain_scores_codex":[0.9975924,0.00142222,0.0001848436,0.0002061901,0.0002796971,0.0003146768],"domain_scores_gemma":[0.9979002,0.0002597084,0.0005633172,0.0003310504,0.0002894266,0.0006562861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7165706,0.2005853,0.002812535,0.002010731,0.001025917,0.0001802895,0.0003523696,0.003136831,0.03995265,0.0003881046,0.00354975,0.02943496],"study_design_scores_gemma":[0.4381517,0.5460182,0.005237385,0.00009856692,0.0003629747,0.0001407781,0.00006177686,0.0008131458,0.004990148,0.0001965527,0.003889539,0.00003913806],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7105296,0.001585244,0.00350856,0.0005504227,0.000263668,0.2764677,0.003402585,0.0002172749,0.003474966],"genre_scores_gemma":[0.6206384,0.001767849,0.009224107,0.001068995,0.0002682025,0.358,0.00521722,0.00005475854,0.00376045],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006820811,"threshold_uncertainty_score":0.03607231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.168095333762312,"score_gpt":0.4938573384575615,"score_spread":0.3257620046952495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}