{"id":"W4402951135","doi":"10.1101/2024.09.27.615468","title":"Mechanism of allosteric activation in human mitochondrial ClpP protease","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Natural Sciences and Engineering Research Council of Canada; McGill University; University of Guelph","funders":"","keywords":"Allosteric regulation; Mechanism (biology); Protease; Chemistry; Cell biology; Biophysics; Biochemistry; Enzyme; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317516,0.0003368707,0.000258267,0.00008515368,0.0001738655,0.0003499363,0.0004545312,0.0003115023,0.001250102],"category_scores_gemma":[0.0001854634,0.000152401,0.000194039,0.0001146738,0.0003527953,0.0003252807,0.000271288,0.000687648,0.0002440643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004052184,"about_ca_system_score_gemma":0.0001865526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006303023,"about_ca_topic_score_gemma":0.0003975118,"domain_scores_codex":[0.9999205,0.00001141106,0.000004456557,0.00002101467,0.00002877838,0.00001391152],"domain_scores_gemma":[0.9999335,0.00001252031,0.00002205018,0.000006877427,0.000009516343,0.00001547855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005939028,0.0001130855,0.001458446,0.0001620487,0.0000461455,0.000858872,0.0001726015,0.00756985,0.9825456,0.002370263,0.0004076622,0.003701447],"study_design_scores_gemma":[0.0002746156,0.0006664876,0.005690564,0.00002885453,0.00003966315,0.001287964,0.0001401604,0.05340066,0.930857,0.00145303,0.006093903,0.00006706027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908654,0.000919268,0.006437064,0.0001698874,0.00002033305,0.00002569995,0.0001542354,0.0001326989,0.001275391],"genre_scores_gemma":[0.9977844,0.0002354425,0.001219249,0.00003089907,0.000002956472,0.000009314694,0.0002320905,0.000007066451,0.0004785023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001250102,"threshold_uncertainty_score":0.004181981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356313693568919,"score_gpt":0.235918363749523,"score_spread":0.2223552268138339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}