{"id":"W4402958146","doi":"10.1186/s13287-024-03915-w","title":"Obesity modulates hematopoietic stem cell fate decision via IL-1β induced p38/MAPK signaling pathway","year":2024,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Northwestern Polytechnical University; Northwestern University","keywords":"Stem cell; Cell biology; Haematopoiesis; Signal transduction; MAPK/ERK pathway; Hematopoietic stem cell; p38 mitogen-activated protein kinases; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046445,0.000397407,0.0001932856,0.0003163724,0.0002059789,0.0002874956,0.000122337,0.0001803379,0.002069966],"category_scores_gemma":[0.0000918131,0.0001584646,0.0003259162,0.0001566247,0.0002783686,0.0002428586,0.0002051047,0.0007627164,0.0002637445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046795,"about_ca_system_score_gemma":0.000247301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002596163,"about_ca_topic_score_gemma":0.0004405269,"domain_scores_codex":[0.9998733,0.00001763365,0.000007613437,0.00002946408,0.00002750267,0.00004442063],"domain_scores_gemma":[0.999934,0.000004927092,0.00002632107,0.000003449437,0.000009842824,0.00002146062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00110991,0.0001427967,0.001969494,0.0001964075,0.00002242531,0.0001204231,0.00006309628,0.0001290244,0.9907449,0.0002588956,0.0002722116,0.00497028],"study_design_scores_gemma":[0.00031744,0.001850077,0.1342562,0.000136857,0.0002388386,0.0007099353,0.0004921491,0.004413252,0.8451079,0.001432161,0.01100086,0.00004436491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899108,0.004412048,0.002600281,0.0002505605,0.0000714825,0.00003431767,0.0005586691,0.0000892003,0.002072634],"genre_scores_gemma":[0.9930553,0.002776629,0.001738962,0.00009303373,0.00002649398,0.00008248968,0.0004047104,0.00001627571,0.001806127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002069966,"threshold_uncertainty_score":0.006924748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05508437569000685,"score_gpt":0.3286174614696344,"score_spread":0.2735330857796275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}