{"id":"W4402961561","doi":"10.1080/15548627.2024.2405956","title":"Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in <i>Drosophila</i> and Vici syndrome patients","year":2024,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Universität zu Köln; National Centre for the Replacement, Refinement and Reduction of Animals in Research; European Commission; Horizon 2020 Framework Programme; Deutsche Forschungsgemeinschaft; Action Medical Research","keywords":"Autophagy; Biology; Epileptogenesis; TFEB; Neuroscience; Cell biology; Neurodegeneration; Epilepsy; Genetics; Pathology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063964,0.0006121761,0.0002681352,0.0005892473,0.0002911979,0.00025208,0.0001616131,0.0004969785,0.001501847],"category_scores_gemma":[0.0002135739,0.0001290515,0.0002679962,0.0002492874,0.0003559651,0.0001559606,0.0002850305,0.0003047045,0.0001739736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003222552,"about_ca_system_score_gemma":0.0001403462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001602241,"about_ca_topic_score_gemma":0.001567361,"domain_scores_codex":[0.9999061,0.00001142368,0.00001689124,0.00003418957,0.00001703844,0.0000143297],"domain_scores_gemma":[0.9998713,0.00001580849,0.00006101205,0.000005204186,0.00001163826,0.00003500848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003811721,0.0004224074,0.22216,0.0003018533,0.0003791382,0.166339,0.0008994417,0.0007814624,0.5760137,0.001696,0.002352542,0.02484274],"study_design_scores_gemma":[0.0001859086,0.001226761,0.671065,0.00008461401,0.0003488143,0.2554127,0.0004711128,0.00234075,0.06106833,0.0006474481,0.007102239,0.00004647036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980044,0.0003223219,0.0003515555,0.00009925133,0.00001009891,0.00001656342,0.000264875,0.00002154005,0.0009093763],"genre_scores_gemma":[0.9989214,0.0001324468,0.0002942698,0.00007725015,0.00000741896,0.000005981165,0.0002199655,0.000008514231,0.0003328404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602241,"threshold_uncertainty_score":0.005024195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006465402758220311,"score_gpt":0.252079715515814,"score_spread":0.2456143127575937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}