{"id":"W4402965375","doi":"10.3390/brainsci14100990","title":"Advancements in Pharmacological Treatment of Alzheimer’s Disease: The Advent of Disease-Modifying Therapies (DMTs)","year":2024,"lang":"en","type":"review","venue":"Brain Sciences","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Medicine; Disease; Clinical trial; Drug development; Alzheimer's disease; Intensive care medicine; Drug; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004898736,0.0004415532,0.001303015,0.000375082,0.0001262265,0.00003192848,0.0003909074,0.00006399209,0.0001822113],"category_scores_gemma":[0.00009299496,0.0002013451,0.0007731328,0.0009944917,0.001104651,0.00009856556,0.0001314187,0.0001456984,0.00003906106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602162,"about_ca_system_score_gemma":0.001717252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003840113,"about_ca_topic_score_gemma":0.000004248418,"domain_scores_codex":[0.9967214,0.0003427529,0.0007234425,0.0006696396,0.001048986,0.0004937829],"domain_scores_gemma":[0.998386,0.0004572409,0.0002882836,0.0003877975,0.00005531901,0.0004253113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003171586,0.002783925,0.001703876,0.005902148,0.0102846,0.0005163144,0.0002135243,0.000007328741,0.000001845808,0.0004317135,0.0004890784,0.9773485],"study_design_scores_gemma":[0.00487385,0.0043281,0.007781139,0.0436375,0.05374187,0.00002817048,0.0006510261,0.0003234941,0.00003640947,0.002132323,0.8813871,0.00107898],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009376869,0.9949633,9.801304e-7,0.000809821,0.0001489305,0.002547027,0.0003058306,0.00002382872,0.0002625651],"genre_scores_gemma":[0.02982091,0.9691488,0.00004678052,0.00004582673,0.00008806046,0.0006665167,0.00007509975,0.00002423874,0.00008377575],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9762695,"threshold_uncertainty_score":0.8210613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2214027862554632,"score_gpt":0.4920766847788839,"score_spread":0.2706738985234207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}