{"id":"W4402970108","doi":"10.1146/annurev-pharmtox-031524-021631","title":"Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review","year":2024,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Drug development; Clinical trial; MEDLINE; Cochrane Library; Population; Disease; Intensive care medicine; Meta-analysis; Drug; Pharmacology; Internal medicine; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02039954,0.001628081,0.005614435,0.01065805,0.0006702815,0.003846962,0.002275095,0.00317029,0.006094863],"category_scores_gemma":[0.05271102,0.0009142412,0.004714844,0.01124878,0.001200883,0.003567104,0.002099704,0.002121518,0.001143264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004434245,"about_ca_system_score_gemma":0.01572642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00311068,"about_ca_topic_score_gemma":0.006999333,"domain_scores_codex":[0.9908186,0.003947127,0.002770686,0.0004112785,0.001804086,0.0002482157],"domain_scores_gemma":[0.9432447,0.04627532,0.005457525,0.0009760997,0.003662084,0.00038425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001922248,0.0000407615,0.0001643875,0.6061696,0.001610926,0.0001124702,0.0002456035,0.0003019228,0.0004419102,0.00272979,0.01046181,0.3775287],"study_design_scores_gemma":[0.0001029441,0.000124774,0.000567125,0.8951624,0.004241256,0.0001889673,0.0001633792,0.0000903634,0.0002017631,0.001647298,0.09748641,0.00002329934],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001058577,0.9983048,0.0002262814,0.0004868235,0.0001990691,0.0001880607,0.00005518433,0.00001057309,0.0004232528],"genre_scores_gemma":[0.001044168,0.997053,0.0007391439,0.000544252,0.00007729148,0.0003289184,0.00007156827,0.000005321569,0.0001363297],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02039954,"threshold_uncertainty_score":0.1078843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1570616094300459,"score_gpt":0.5753460924345787,"score_spread":0.4182844830045328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}