{"id":"W4402970398","doi":"10.1038/s42003-024-06716-2","title":"Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Trace Elements in Health","field":"Nursing","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Engineering Research Board; National Institutes of Health; The Wellcome Trust DBT India Alliance; Department of Science and Technology, Ministry of Science and Technology, India; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India; Indian Institute of Science Education and Research Pune; Wellcome Trust; National Institute of General Medical Sciences; Indian Institute of Science Education and Research Mohali; Canadian Institute for Advanced Research","keywords":"Homeostasis; Leishmania; Host (biology); Immunology; Biology; Cell biology; Virology; Parasite hosting; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009309487,0.0001841013,0.0001756198,0.0001394985,0.0001066802,0.0002633829,0.000118418,0.0002298244,0.00118701],"category_scores_gemma":[0.00009249704,0.000105433,0.0001308696,0.00006948042,0.0002201773,0.00014677,0.0002235203,0.0004285351,0.0002501658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889029,"about_ca_system_score_gemma":0.0001605922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025067,"about_ca_topic_score_gemma":0.0005412813,"domain_scores_codex":[0.9998537,0.00002548237,0.000006942973,0.00002792024,0.0000209494,0.00006490807],"domain_scores_gemma":[0.9999329,0.000005688234,0.00001761519,0.000008151081,0.00001192521,0.00002374824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386252,0.00002815134,0.0004722924,0.00004002536,0.000003394937,0.00008555451,0.00001831692,0.00002002311,0.9978576,0.0001222761,0.0001224828,0.001091184],"study_design_scores_gemma":[0.00004043711,0.001004302,0.02487021,0.00002632011,0.00004110914,0.0009772287,0.0002117903,0.001443217,0.9651464,0.000373163,0.005854341,0.00001161873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945111,0.001709204,0.001253678,0.0001912135,0.00003054492,0.00002252022,0.0002052326,0.0001040397,0.001972344],"genre_scores_gemma":[0.9968954,0.0003643891,0.000429514,0.00006297805,0.000009415233,0.00002129174,0.0001357229,0.000008562698,0.002072796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118701,"threshold_uncertainty_score":0.003970921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04183342497173611,"score_gpt":0.3379654411233396,"score_spread":0.2961320161516035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}