{"id":"W4402990365","doi":"10.3390/nu16193309","title":"Oral Trehalose Intake Modulates the Microbiota–Gut–Brain Axis and Is Neuroprotective in a Synucleinopathy Mouse Model","year":2024,"lang":"en","type":"article","venue":"Nutrients","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Fondation CHU de Québec; Université Laval","keywords":"Neuroprotection; Gut–brain axis; Trehalose; Gut flora; Biology; Neuroscience; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421696,0.0008101607,0.00073613,0.0008194084,0.0002493559,0.0003906212,0.0003434997,0.0007496572,0.001733642],"category_scores_gemma":[0.0001186425,0.0002789135,0.0006611566,0.0002834309,0.0004202418,0.0005252045,0.0002415859,0.001943434,0.0003472923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221085,"about_ca_system_score_gemma":0.0003013875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086465,"about_ca_topic_score_gemma":0.002093784,"domain_scores_codex":[0.9997882,0.00002689118,0.0000195555,0.0000572135,0.00004301614,0.0000650577],"domain_scores_gemma":[0.9998351,0.000007049186,0.00005227623,0.00001494852,0.00002149182,0.00006902484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002211268,0.0004678121,0.0003687322,0.00008533926,0.0000288998,0.0001071781,0.00003137148,0.00006346031,0.9945139,0.00005940467,0.000121273,0.001941317],"study_design_scores_gemma":[0.0003493069,0.008161479,0.01836376,0.00005758056,0.0002060109,0.0003435236,0.0001782469,0.001793487,0.9668401,0.0003014451,0.003361124,0.00004408274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994141,0.001944616,0.001141578,0.0003145502,0.00008881285,0.00006944737,0.001076545,0.0001769586,0.001046418],"genre_scores_gemma":[0.9883333,0.001956431,0.002326701,0.0002216363,0.00003464482,0.0002825047,0.001145012,0.00004630598,0.005653574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001733642,"threshold_uncertainty_score":0.005799592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996092809084269,"score_gpt":0.2487844926830791,"score_spread":0.2288235645922364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}