{"id":"W4402990500","doi":"10.3390/cancers16193322","title":"Post-Transcriptional Modifications to miRNAs Undergo Widespread Alterations, Creating a Unique Lung Adenocarcinoma IsomiRome","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"microRNA; ADAR; Adenocarcinoma; RNA editing; Lung cancer; Biology; Epigenetics; Transcriptome; Computational biology; Bioconductor; Cancer research; Oncology; Gene expression; Cancer; Bioinformatics; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005223188,0.000109063,0.00006756214,0.00007688445,0.0001215122,0.00009284617,0.0000994506,0.00006480643,0.0001122695],"category_scores_gemma":[0.00004835386,0.0001143228,0.00008171189,0.0001355651,0.00003661979,0.00001115407,0.00001909275,0.00005202928,0.00002939359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002281242,"about_ca_system_score_gemma":0.0007770871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171997,"about_ca_topic_score_gemma":0.0001082234,"domain_scores_codex":[0.9992587,0.00003180998,0.0001540429,0.0003064035,0.00009924861,0.0001498111],"domain_scores_gemma":[0.9995,0.00001511439,0.00001977379,0.0002132366,0.00008814707,0.0001637157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007328793,0.00001343867,0.00156862,0.0000554287,0.00007654781,0.000005364699,0.0003192757,0.008842116,0.9599745,0.01790414,0.01080582,0.0003615052],"study_design_scores_gemma":[0.002838802,0.0008885149,0.2546308,0.0007690419,0.0004811827,0.0001527723,0.002447301,0.08355664,0.3080375,0.002497277,0.3410153,0.002684846],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662357,0.004637754,0.02278284,0.002808829,0.0003675567,0.0003507867,0.0002440529,0.00006752723,0.002504929],"genre_scores_gemma":[0.9923576,0.00006397261,0.0009764417,0.001211416,0.0002203018,0.0001264867,0.0003945767,0.00002154966,0.004627661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6519369,"threshold_uncertainty_score":0.4661948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013688417493637,"score_gpt":0.2786253171646263,"score_spread":0.2649368996709893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}