{"id":"W4403004702","doi":"10.3389/jpps.2024.13375","title":"Targeting ketone body metabolism to treat fatty liver disease","year":2024,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Universities Space Research Association; Government of Ontario; Diabetes Canada; Mitacs; Heart and Stroke Foundation of Canada","keywords":"Ketogenesis; Ketone bodies; Cirrhosis; Steatohepatitis; Fatty liver; Liver disease; Hepatocellular carcinoma; Medicine; Fatty acid metabolism; Endocrinology; Internal medicine; Disease; Metabolism; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035681,0.0006681987,0.001042392,0.001839925,0.0002205203,0.0007220574,0.0005742299,0.0007390128,0.004456686],"category_scores_gemma":[0.0004093672,0.0001952041,0.0006146579,0.001167715,0.0002269706,0.0006588177,0.0004881137,0.001555508,0.00173299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003387139,"about_ca_system_score_gemma":0.0005715338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007613063,"about_ca_topic_score_gemma":0.001709456,"domain_scores_codex":[0.9998785,0.00001859741,0.00001753025,0.00002119921,0.00004900575,0.00001514043],"domain_scores_gemma":[0.9998778,0.00004833119,0.00002170581,0.000004124458,0.00003514211,0.00001289492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001145104,0.000168614,0.0001451389,0.027209,0.0001720194,0.0001981858,0.00006015606,0.0004135812,0.00429534,0.002817414,0.0188662,0.9455398],"study_design_scores_gemma":[0.00004325774,0.0002378121,0.001011369,0.004851339,0.0002592943,0.001158761,0.00005326296,0.0001696739,0.00136867,0.001533387,0.9892915,0.00002167856],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003474829,0.9976928,0.0001768811,0.0001845547,0.0001861235,0.000008826797,0.00002770577,0.00001323258,0.001362433],"genre_scores_gemma":[0.001357665,0.9975215,0.0002240744,0.0001330716,0.00007275194,0.000008222812,0.00003700663,0.000001624989,0.0006441025],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004456686,"threshold_uncertainty_score":0.01490915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1507587108300319,"score_gpt":0.4837618264010292,"score_spread":0.3330031155709973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}