{"id":"W4403007833","doi":"10.1038/s41420-024-02183-0","title":"TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells","year":2024,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Advance Queensland; National Health and Medical Research Council; Queensland Government; University of Queensland","keywords":"Endoplasmic reticulum; Cell biology; STIM1; Cancer cell; Inositol; Biology; Receptor; Chemistry; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007351853,0.0001570327,0.0002355096,0.0005043948,0.0003050937,0.000427962,0.0001117784,0.0003281469,0.002531993],"category_scores_gemma":[0.0001781101,0.0001258103,0.0001385115,0.0004318282,0.0001642493,0.0001416862,0.0001832913,0.0004231367,0.0006827228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004148756,"about_ca_system_score_gemma":0.0001729499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007457905,"about_ca_topic_score_gemma":0.0007272603,"domain_scores_codex":[0.9998887,0.000008261015,0.000005578824,0.00002067503,0.00003486862,0.00004184868],"domain_scores_gemma":[0.9998317,0.00001414775,0.00005727139,0.000008445734,0.00003642034,0.0000519014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005308883,0.00003935856,0.006502138,0.00009072143,0.00001429585,0.0002576781,0.00004181821,0.00004140645,0.9899339,0.00008132138,0.0004450284,0.002021409],"study_design_scores_gemma":[0.00007301503,0.0004137897,0.4588233,0.00004561784,0.0000837488,0.003494232,0.0005659846,0.001945063,0.5176007,0.0002041659,0.01672793,0.00002261419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914471,0.004849219,0.0004225083,0.000266834,0.00005547116,0.00001855607,0.001002718,0.00009465415,0.001842904],"genre_scores_gemma":[0.9948768,0.001006821,0.0003158896,0.0001038864,0.00002081028,0.00003308435,0.001262328,0.00001107509,0.002369357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002531993,"threshold_uncertainty_score":0.008470416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267864737112553,"score_gpt":0.2634312684033824,"score_spread":0.2507526210322569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}