{"id":"W4403007959","doi":"10.1002/adhm.202400509","title":"Inhalable Dry Powders for Lung mRNA Delivery","year":2024,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Sanofi; National Cancer Institute; National Institutes of Health; Alpha-1 Foundation; Cystic Fibrosis Foundation","keywords":"Aerosolization; Inhalation; Messenger RNA; In vivo; Dry-powder inhaler; Lung; Pharmacology; Materials science; Chromatography; Chemistry; Nanotechnology; Medicine; Biology; Immunology; Biochemistry; Biotechnology; Anesthesia; Inhaler; Asthma; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004236282,0.0003613487,0.0003672291,0.0003662301,0.0001418612,0.0003967989,0.0002666568,0.0004572483,0.00151193],"category_scores_gemma":[0.0003139683,0.0001486035,0.0003442306,0.0001653178,0.0002706156,0.000419316,0.0002489931,0.0007205338,0.0008167265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811308,"about_ca_system_score_gemma":0.0001592532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001669343,"about_ca_topic_score_gemma":0.000292444,"domain_scores_codex":[0.9997947,0.00003233092,0.00001445333,0.00003821973,0.0001076983,0.00001262581],"domain_scores_gemma":[0.9998863,0.00003364129,0.00004004569,0.00001058745,0.00001901672,0.00001038608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004802108,0.00005126239,0.0001502845,0.0002288121,0.00001457741,0.000103567,0.00002009617,0.0002487781,0.9675877,0.0005435177,0.0004760491,0.03052748],"study_design_scores_gemma":[0.00005169792,0.001152059,0.001234415,0.00005194284,0.00004753125,0.0009031049,0.00003289898,0.002401597,0.9694842,0.0003934394,0.0242318,0.00001544403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4069906,0.07661123,0.4920043,0.001527522,0.001127249,0.001178495,0.0008893011,0.001993865,0.01767743],"genre_scores_gemma":[0.7125483,0.03455822,0.2370605,0.000941438,0.0003092329,0.0004700572,0.0008653625,0.0003072813,0.01293964],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00151193,"threshold_uncertainty_score":0.005057931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064650299474363,"score_gpt":0.3331614397355551,"score_spread":0.3125149367408114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}