{"id":"W4403007959","doi":"10.1002/adhm.202400509","title":"Inhalable Dry Powders for Lung mRNA Delivery","year":2024,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Sanofi; National Cancer Institute; National Institutes of Health; Alpha-1 Foundation; Cystic Fibrosis Foundation","keywords":"Aerosolization; Inhalation; Messenger RNA; In vivo; Dry-powder inhaler; Lung; Pharmacology; Materials science; Chromatography; Chemistry; Nanotechnology; Medicine; Biology; Immunology; Biochemistry; Biotechnology; Anesthesia; Inhaler; Asthma; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003187074,0.0001904566,0.0003804974,0.0001768745,0.0001531507,0.00006135416,0.00006254591,0.000157394,0.0003526264],"category_scores_gemma":[0.00006448088,0.0001635976,0.0001026478,0.0001705335,0.00004196889,0.000211193,0.00002792593,0.0001201255,0.0001246444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962622,"about_ca_system_score_gemma":0.000328489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005078585,"about_ca_topic_score_gemma":0.000007291534,"domain_scores_codex":[0.9984952,0.00006169172,0.0004638281,0.0003838739,0.0001919761,0.0004034452],"domain_scores_gemma":[0.9991761,0.0001045098,0.00006790669,0.0002547177,0.0002181407,0.0001785556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0011598,0.00009680014,0.000544677,0.01283642,0.000199044,0.0002954749,0.00111254,0.00008615042,0.9121774,0.00688127,0.0143742,0.05023617],"study_design_scores_gemma":[0.002765248,0.0005616058,0.0003876389,0.002345842,0.0001686042,0.00008659005,0.0007942837,0.0009363237,0.7636719,0.0005712641,0.2271086,0.0006021106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790211,0.007227333,0.0006906901,0.00613544,0.004047813,0.001606122,0.0002183975,0.0005008513,0.0005522348],"genre_scores_gemma":[0.9883163,0.0005118928,0.002830116,0.004738457,0.000722972,0.0001835137,0.0001918717,0.00007461123,0.002430298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2127344,"threshold_uncertainty_score":0.6671317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064650299474363,"score_gpt":0.3331614397355551,"score_spread":0.3125149367408114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}