{"id":"W4403011600","doi":"10.1126/scisignal.adk2345","title":"A human DCC variant causing mirror movement disorder reveals that the WAVE regulatory complex mediates axon guidance by netrin-1–DCC","year":2024,"lang":"en","type":"article","venue":"Science Signaling","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; McGill University Health Centre; Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; China Scholarship Council; National Institutes of Health; National Science Foundation","keywords":"Netrin; Axon guidance; Deleted in Colorectal Cancer; Biology; Cell biology; Axon; Cytoplasm; Sequence motif; Genetics; HEK 293 cells; Receptor; Gene; Colorectal cancer; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.002972208,0.000442884,0.0003578801,0.0002959194,0.002385759,0.0009578747,0.001121237,0.00008604535,0.0003612204],"category_scores_gemma":[0.0004527221,0.0003218938,0.0001763214,0.002106628,0.001466964,0.0009937958,0.0004481272,0.0005248691,0.00006102044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440234,"about_ca_system_score_gemma":0.000266381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001698937,"about_ca_topic_score_gemma":0.00001604789,"domain_scores_codex":[0.9941892,0.0002811151,0.0007040991,0.001552005,0.002038843,0.001234739],"domain_scores_gemma":[0.997986,0.0006671215,0.0002673212,0.000712548,0.0001010013,0.0002659727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008236923,0.00004170217,0.0001676331,0.00004860397,0.000006360666,0.0001229548,0.0006970547,0.0003285297,0.9912868,0.00529021,0.001082873,0.0009190775],"study_design_scores_gemma":[0.0003027022,0.0001343336,0.001449228,0.0005155618,0.00003842697,0.00007047904,0.0004844041,0.01670369,0.9674818,0.00620042,0.005955792,0.000663154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896657,0.002265023,0.002367345,0.00219678,0.001092105,0.0007595644,0.00004628136,0.0003486832,0.00125854],"genre_scores_gemma":[0.9943719,0.00005353005,0.0003782698,0.004161793,0.0001965745,0.00005875195,0.000003681335,0.00005746853,0.0007180405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02380496,"threshold_uncertainty_score":0.9999233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07821397281188752,"score_gpt":0.309876455046988,"score_spread":0.2316624822351005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}